三黄桃红油纱促进动物体表创面愈合机理的实验研究

Sanhuang Taohong Gauze Strip Promoting Wound-Surface Healing of Animals Body Surface： Experimental Research for Its Mechanism

为研究三黄桃红油纱促进肛瘘创面愈合的机理，将36只SD大鼠随机分为3组，实验组（三黄桃红油纱组）、对照组（凡士林油纱组）和空白组，每组12只。实验组和对照组建立动物体表瘘管模型，空白组不做任何处理。用药5d后取创面组织，比较不同分组之间的细菌定植情况、创面组织中TNF-α和IL-10水平、创面EGF水平。结果显示，肉眼观察发现，实验组创面菌落定植少于对照组。实验组、对照组、空白组，任意2组间创面TNF-α、IL-10、EGF水平比较差异均有统计学意义，P〈0．01；但实验组各指标数据更接近空白组。结果表明，三黄桃红油纱可以减少肛瘘创面的细菌定植、减轻炎性反应、促进EGF释放，从而加快肛瘘创面的愈合过程。

In order to study the mechanism of Sanhuang Taohong gauze strip in the promoting wound-surface healing of anal fistula,authors randomly divided 36 SD rats into three groups：experimental group（i.e Sanhuang Taohong gauze strip group, shorter named as ST group）, control group（i.e petrolatum gauze strip group） and blank group, 12 per group,which ST group and control group were established animals＂ model of fistula on body＇s surface, blank group without any management; 5 days after medication took wound-surface tissue to compare the status on bacteria eolonization,TNF-α and IL-10 level in wound-surface tissue and wound-surface EGF level among the three groups. As results, ST group was significantly less than control group in bacteria colonization of wound;in the level of IL-10,TNF-α and EGF,there was statistical difference among all groups（ P 〈0.01）;but all indexes of ST group was closer to blank group. Results show that Sanhuang Taohong gauze strip can promote wound surface healing thanks to reducing bacteria colonization on wound surface and alleviating inflammatory response and accelerating EGF release.