复方苦参注射液联合化疗对晚期肺癌患者外周血调节性T、B淋巴细胞的影响

Compound Kushen Injection Combined with Chemotherapy in Influencing PB Regulatory T and B Lymphocytes in Advanced Lung Cancer Patients

目的探讨复方苦参注射液联合化疗对晚期肺癌患者外周血调节性T、B淋巴细胞的影响。方法收集我院肿瘤科晚期肺癌患者46例,随机分为复方苦参注射液联合化疗组(A组)、单纯化疗组(B组)各23例,观察并比较两组治疗前后外周血CD4+CD25+调节性T淋巴细胞(Tregs)和CDl9(+)IL-10(+)调节性B淋巴细胞(Bregs)的变化特征。结果化疗前两组患者Tregs、Bregs水平差异无统计学意义(P>0.05);与治疗前比较,两组Tregs均较治疗前有所下降,差异有统计学意义(P<0.05),Bregs变化差异无统计学意义(P>0.05);A组治疗后Tregs水平高于B组,差异有统计学意义(P<0.05)。结论晚期肺癌患者化疗后免疫功能降低,化疗时配合复方苦参注射液能提高机体免疫力,改善患者生活质量。

Objective To discuss the compound kushen injection combined with chemotherapy in influencing the PBl regulatory T and B lymphocytes in the patients with advanced lung cancer.Methods 46 cases of patients with advanced lung cancer admitted and treated in our hospital were randomly divided into group A（patients were given compound kushen injection combined with chemotherapy）and group B（patients were given merely chemotherapy）with each group 23 cases.Observe and compare the change features of PB CD4＋CD25＋ regulatory T lymphocytes（Tregs）and CDl9（＋）IL-10（＋）regulatory B lymphocytes（Bregs）.Results Before chemotherapy,the difference of Tregs and Bregs levels in both groups showed no statistical significance（P 〉0.05）.Compared with those of before chemotherapy,the Tregs levels in both groups were more decreased after the chemotherapy.The difference showed a statistical significance（P〈0.05）.While the Bregs change difference showed no statistical significance（P〉0.05）.After chemotherapy,the Tregs level in group A was higher than group B.The difference showed a statistical significance（P 〈0.05）.Conclusion The immunity in patients with advanced lung cancer decreased after chemotherapy.Compound kushen injection combined with chemotherapy can increase the patients＇ immunity and improve their life quality.