调强适形放疗同步化疗治疗复发性宫颈癌的效果观察

Observation on Curative Effects of Intensive Modulated Radiation Therapy Plus Chemotherapy in Treating Recurrent Cervical Carcinoma

目的探究调强适形放疗同步化疗治疗复发性宫颈癌的疗效。方法选取2014年7月至2016年7月经我院化疗后复发的宫颈癌患者76例为研究对象,按照随机数字表法将其分为观察组(n=38)与对照组(n=38),对照组采用常规三维适形放疗,观察组采用调强适形放疗同步化疗,比较两组患者疗效、不良反应、近期生存率和转移率。结果观察组疗效总有效率(86.84%)显著高于对照组(63.16%),差异具有统计学意义(P=0.0171);观察组白细胞下降Ⅱ~Ⅲ的发生率(31.58%)显著低于对照组(63.16%),差异具有统计学意义(P<0.05);两组患者近期生存率和转移率比较差异无统计学意义(P>0.05)。结论调强适形放疗同步化疗治疗复发性宫颈癌疗效明确,安全性高,值得推广应用。

Objectives To study the curative effects of intensive modulated radiation therapy plus chemotherapy in treating recurrent cervical carcinoma.Methods 76 cases of patients with recurrent cervical carcinoma after chemotherapy admitted and treated in our hospital during July 2014 and July 2016 were selected as the study objectives.They were randomly divided into observation group（n=38）and contrast group（n=38）.Patients in the contrast group were given conventional 3 d chemoradiotherapy,while patients in the observation group were given intensive modulated radiation therapy plus chemotherapy.Compare the curative effects,adverse reaction,current survival rate and transfer rate.Results The total effective rate in the observation group（86.84%）was significantly higher than the contrast group（63.16%）.The difference showed a statistical significance（χ~2=5.6842,P=0.0171）.The leukocyte decline rate in II to III stage in the observation group（31.58%）was significantly lower than the contrast group（63.16%）.The difference showed a statistical significance（P〈0.05）.The comparison of the current survival rate and transfer rate showed no statistical significance（P〉0.05）.Conclusion Intensive modulated radiation therapy plus chemotherapy is proved to be effective in treating recurrent cervical carcinoma with high security.Thus,it deserves to be widely promoted.