普通肝素联合活血通络方对长期卧床老年下肢深静脉血栓的治疗价值

Therapeutic Effect of Common Heparin Combined with Huoxue Tongluo Recipe on long term Bedridden Elderly Patients with deep vein Thrombosis

目的探究普通肝素联合活血通络组方对于长期卧床老年下肢深静脉血栓形成(DVT)的治疗效果。方法选取2014年1月至2017年6月我院收治的100例长期卧床合并下肢DVT老年患者为研究对象,随机分为对照组和治疗组各50例,对照组给予普通肝素治疗,治疗组在对照组基础上加用活血通络方。两组均于治疗前及治疗后测定血液流变学指标和凝血功能,比较两组临床疗效并记录不良反应。结果两组血液流变学指标、凝血功能指标均得到明显改善(P<0.05),治疗组改善情况及临床疗效明显优于对照组(P<0.05),治疗组出血例数明显少于对照组(P<0.05)。结论普通肝素联合活血通络方对长期卧床老年下肢DVT治疗效果明显,安全性优于单用普通肝素。

Objective To investigate the therapeutic effect of unfractionated heparin combined with Huoxuetongluo Chinese medicine on deep venous thrombosis（DVT） of long-term bed-rest elderly. Methods Total 100 long-term bed-rest elderly with DVT from January 2014 to June 2017 were enrolled and divided into control group and treatment group randomly, 50 cases in each group. Control group was treated with unfractionated heparin. Treatment group added Huoxuetongluo Chinese medicine on the basis of control group. Hemorheological parameters and coagulation function were measured before and after treatment. The clinical efficacy and adverse reaction were compared between the two groups. Results The hemorheological parameters and coagulation function of two groups were improved significantly （ P 〈 0. 05 ）. The improvement and the clinical efficacy of treatment group were significantly better than control group （ P 〈 0. 05 ）. The number of bleeding cases in treatment group was significantly lower than that in control group （ P 〉 0.05 ）. Conclusion Unfractionated heparin combined with Huoxuetongluo Chinese medicine has obvious effect on the treatment of DVT of long-term bed-rest elderly and its safety performance is superior to single unfractionated heparin.