孟鲁司特钠治疗小儿支气管哮喘合并变应性鼻炎的疗效观察

Observation on the curative effect of montelukast sodium in treatment of bronchial asthma complicated with allergic rhinitis in children

目的探讨孟鲁司特钠治疗小儿支气管哮喘合并变应性鼻炎的疗效,为临床治疗提供参考。方法选取2015年4月-2016年4月在成都市第五人民医院接受治疗的小儿支气管哮喘合并变应性鼻炎患儿96例为研究对象,采用随机数表法将所有的入选患儿分为两组,即观察组和对照组各48例。观察组患儿给予孟鲁司特钠治疗,对照组患儿给予氯雷他定治疗,观察两组患儿治疗后的气道反应性变化、变应性鼻炎症状评分、感冒症状评分以及支气管哮喘症状评分,同时比较两组患儿治疗后的临床疗效。结果治疗后,两组患儿的最大呼气量(FEV)以及呼气流量峰值(PEF)都有所升高,观察组(2.89±0.52)L、(6.29±0.45)L/s高于对照组(2.24±0.58)L、(5.38±0.58)L/s,两组比较差异有统计学意义(均P<0.05);患儿的哮喘症状、变应性鼻炎症状以及感冒症状的评分均有所降低,观察组(2.01±0.12)分、(2.45±0.58)分、(1.02±0.12)分/月低于对照组(3.56±0.56)分、(3.89±0.48)分、(1.68±0.28)分/月,两组比较差异有统计学意义(均P<0.05);观察组患儿治疗后的总有效率为93.75%高于对照组患儿的75.00%,两组比较差异有统计学意义(P<0.05);观察组患儿不良反应发生率为10.42%低于对照组患儿27.08%,两组比较差异有统计学意义(P<0.05)。结论采用孟鲁司特钠治疗小儿支气管哮喘合并变应性鼻炎,能够有效地改善患儿的气道反应性变化,改善患儿的临床症状,疗效显著。

Objective To explore the curative effect of montelukast sodium in treatment of bronchial asthma complicated with allergic rhinitis in children, and provide a reference for clinical treatment. Methods Ninety-six children with bronchial asthma complicated with al- lergic rhinitis treated in the Fifth People＇s Hospital of Chengdu from April 2015 to April 2016 were selected and divided into observation group and control group according to random number table, 48 children in each group. The children in observation group were treated by mon- telukast sodium, and the children in control group were treated by loratadine. The changes of airway responsiveness, scores of allergic rhinitis symptoms, cold symptoms, and bronchial asthma symptoms after treatment in the two groups were observed. The clinical effects after treat- ment in the two groups were compared. Results After treatment, forced expiratory volume （FEV） and peak expiratory flow （PEF） in the two groups increased. FEV and PEF after treatment in observation group were （2. 89±0. 52） L and （6. 29±0. 45） L/s, respectively, which were statistically significantly higher than those in control group [ （2. 24±0. 58 ） L and （5.38±0. 58） L/s ] （P〈0. 05） . The scores of bron- chial asthma symptoms, allergic rhinitis symptoms, and cold symptoms after treatment in the two groups decreased. The scores of bronchial asthma symptoms, allergic rhinitis symptoms, and cold symptoms after treatment in observation group were （2.01±0. 12）, （2.45±0. 58）, and （ 1.02±0. 12）, respectively, which were statistically significantly lower than those in control group [ （3.56±0. 56）, （3.89±0.48）, （ 1.68±0. 28 ） ] （ all P〈0. 05 ） . The total effective rate after treatment in observation group was 93.75%, which was statistically significant- ly higher than that in control group （75.00%） （P〈0. 05 ） . The incidence rate of adverse reactions in observation group was 10. 42% , which was statistically significantly lower than that in control group （27.08%） （P〈0. 05） . Conclusion Montelukast sodium can effective- ly improve airway responsiveness and clinical symptoms of children with bronchial asthma and allergic rhinitis, the effect is significant.