保留膀胱术联合化疗治疗局部浸润性膀胱癌的临床观察

Clinical Observation on Bladder Preserving Combined With Chemotherapy in the Treatment of Local Invasive Bladder Cancer

目的探讨保留膀胱术联合化疗治疗局部浸润性膀胱癌的临床观察。方法收集2014年1月—2016年2月在我院治疗的局部浸润性膀胱癌患者180例,随机分为研究组和对照组。两组基础手术方法均为行经尿道膀胱肿瘤电切术,同时对照组术后给予吉西他滨+顺铂化疗,研究组加用膀胱灌注丝裂霉素。对比两组治疗结束随访1年肿瘤复发情况。结果两组一般资料(性别、年龄、肿瘤分期、肿瘤直径)比较差异无统计学意义(P>0.05);研究组和对照组治疗结束随访1年肿瘤复发率分别为0%(0/90)、5.55%(5/90),比较差异有统计学意义(P<0.05)。结论保留膀胱术联合化疗治疗局部浸润性膀胱癌的疗效肯定,能够延长患者生存期。

Objective To investigate the clinical observation of bladder preserving combined with chemotherapy in the treatment of local invasive bladder cancer. Methods From January 2014 to December 2016, 180 cases patients with local invasive bladder cancer were randomly divided into the study group and the control group. The two groups were treated by transurethral resection of bladder tumor. Gemcitabine plus cisplatin chemotherapy was given after operation. The patients in the study group were given bladder perfusion mitomycin. The general data of the two groups before treatment were analyzed, and the recurrence of the tumor in the two groups was compared for 1 year. Results There was no difference between the two groups of general data （sex, age, tumor staging, tumor diameter） （P 〉 0.05）. The recurrence rates of tumor in the 1 year follow-up period of the study group and the control group were 0% （0/90） and 5.55% （5/90）, there was a statistically significant difference in comparison （P 〈 0.05）. Conclusion The curative effect of bladder preserving combined with chemotherapy in the treatment of local invasive bladder cancer is positive and can prolong the survival period of the patients.