替加环素联合头孢哌酮舒巴坦治疗多重耐药鲍曼不动杆菌肺炎的临床分析

Clinical Analysis of Tigecycline Combined Cefoperazone Sulbactam Treatment in Multidrug–Resistant Acinetobacter Baumannii Pneumonia

目的研究多重耐药鲍曼不动杆菌肺炎用头孢哌酮舒巴坦联合替加环素治疗的效果。方法选取104例多重耐药鲍曼不动杆菌肺炎患者,分为对照组和治疗组,每组52例。分别单纯用替加环素治疗,和头孢哌酮舒巴坦联合替加环素治疗。结果治疗组炎症因子指标用药后改善优于对照组(P<0.05);病情控制总有效率为90.4%,对照组为67.3%(P<0.05);不良反应仅有2例,对照组8例(P<0.05)。结论多重耐药鲍曼不动杆菌肺炎采用头孢哌酮舒巴坦联合替加环素治疗,可迅速改善炎症因子指标,缩短用药时间,减少不良反应,提高有效率。

Objective To study the efficacy of cefoperazone sulbactam combined with tegacycline in multiple drug resistant acinetobacter bauman pneumonia. Methods 104 cases of multidrug-resistant acinetobacter bauman pneumonia were divided into the control group and the treatment group, with 52 cases in each group. They were treated with tegocycline, or tegocycline combined with cefoperazone sulbactam. Results The level of inflammatory factors in the treatment group was significantly better than that in the control group （P 〈 0.05）; the total effective rate of disease control was 90.4%, while that of the control group was 67.3% （P 〈 0.05）; there were only 2 cases of adverse reactions and 8 cases of the control group （P 〈 0.05）. Conclusion Multidrug-resistant acinetobacter bauman pneumonia treated with cefoperazone sulbactam combined with tegacycline, the index of inflammatory factors can be rapidly improved and shorten the time of drug use, reduce adverse reactions, improve efficiency.