苄星青霉素联合头孢三嗪对梅毒患者的疗效及安全性影响

Curative Effect and Safety of Benzathine Penicillin Joint Cephalosporins Triazine in Patients With Syphilis

目的了解苄星青霉素联合头孢三嗪对梅毒患者的疗效及安全性影响。方法选择66例因梅毒于2016年1—12月接受治疗的患者,随机分组:苄星青霉素+头孢三嗪治疗的33例作研究组,苄星青霉素治疗的33例作对照组,对比两组临床疗效、安全性。结果展开不同方法治疗后,33例研究组有效率96.97%(32/33),比33例对照组的81.82%(26/33)高,P<0.05;研究组RPR阴性率93.94%(31/33),与对照组78.79%(27/33)相比差异有统计学意义(P<0.05)。结论临床对梅毒患者展开专业治疗时,通过展开苄星青霉素联合头孢三嗪疗法治疗,疗效确切,可在提升患者临床治疗有效率的基础上,提高RPR阴性,具有较高的临床应用价值。

Objective To understand the efficacy and safety of penicillin combined with ceikiaxone triazine in patients with syphilis. Methods Sixty- six patients with syphilis were enrolled and treated in our hospital from January to December 2016. Patients were randomly assigned into two groups： study group was treated with benzathine penicillin and ceftriaxone, control group was treated with benzathine penicillin, the clinical efficacy and safety of the two groups was compared. Results Aiter the treatment with different methods, the effective rate of the study group was 96.97% （32/33）, which was higher than that of the 33 cases （81.82%, 26/33） （P 〈 0.05）. The RPR negative rate of the study group was 93.94 % （31/33） compared with 78.79% （27/33） in the control group （P 〈 0.05）. Conclusion Clinical treatment of syphilis in patients with professional treatment, through the combination of benzathine penicillin and ceftriaxone therapy, the exact effect, can improve the clinical efficacy of patients based on the RPR-negative, with high clinical value.