Notch信号通路在骨重建中的作用

The Role of Notch Signaling in Bone Remodeling

Notch信号通路在胚胎发育、神经系统、血管系统、内分泌系统及肿瘤等领域具有广泛的影响。近年来的研究表明,Notch对于骨组织代谢尤其是骨重建有着重要的调控作用,而骨重建的调节紊乱和骨质疏松、骨关节炎等疾病的进展密切相关。Notch信号通路可以通过调控骨组织不同细胞的功能从而影响骨重建过程,但其在不同细胞中具体的参与方式仍然未知。综述近年来Notch信号通路在骨重建中的作用研究进展。

Notch signaling pathway has a wide range of effects in the field of embryonic development,nervous system,vascular system,endocrine system and tumor. In recent years,studies have shown that Notch plays an important role in the regulation of bone metabolism,especially in bone remodeling. The disorder of bone remodeling is closely related to the progress of diseases such as osteoporosis and osteoarthritis. Notch signaling pathway can affect the process of bone remodeling by regulating the function of different cells in bone tissues,but its specific participation in different cells is still unknown. This review summarizes recent advances about the role of Notch signaling in bone remodeling.