右美托咪定对感染性休克患者早期目标导向镇静方案的临床研究

Clinical study of dexmedetomidine in early goal-directed sedation in patients with septic shock

目的探究右美托咪定对感染性休克患者早期目标导向镇静方案的有效性和安全性。方法本次试验研究选择的试验对象是2015年8月至2016年12月我科接收并治疗的感染性休克患者70例,并通过随机样表法分为对照与研究两组,对照组32例抽取的对象按照常规镇静治疗,即选择应用咪达唑仑治疗,研究组抽取的38例感染性休克患者选择应用右美托咪定进行镇静治疗,观察并分析两组感染性休克患者应用不同镇静方法的有效性与安全性等。结果两组患者不同方法治疗,治疗后研究组感染性休克患者的镇静程度、苏醒时间、机械通气时间、生命体征稳定等指标明显优于对照组的常规镇静治疗,效果差异性较大(P<0.05)。结论针对感染性休克患者早期目标导向镇静治疗中选择应用右美托咪定其安全性和有效性较好,值得在临床治疗中应用。

Objective To investigate the efficacy and safety of early goal-directed sedation with dexme- detomidine in patients with septic shock. Methods This study is selected from August 2015 to December 2016 in our department 70 patients receiving treatment of septic shock , and through random sample table method divided into the control group and the study group two, there were 32 cases in control group, the control group selected ob- ject according to the conventional sedation treatment, namely the application of midazolam extraction treatment, the study group of 38 patients with septic shock in patients with application of dexmedetomidine sedation, analysis and application of different sedation method analysis of two groups of patients with septic shock. The efficacy and safety of observation and etc. Results Two groups of patients with different treatment methods, The onset time of the study group of patients with septic shock after sedation, h recovery time and time of mechanical ventilation was obviously better than the control group, the effect of difference （P 〈 0.05 ） , has significant research value. Conclusions For patients with septic shock early goal orientation selection and application of sedation of dexmedetomidine can play a better effect, the more safe and effective, sedation score is high, it is worth of application in clinical treatment.