PCT、CRP、WBC和N%在细菌感染性疾病中的诊断价值评估

Evaluation of PCT,CRP,WBC and N% in the diagnosis and treatment of common pathogenic bacteria

目的探讨降钙素原(PCT)、C反应蛋白(CRP)、白细胞(WBC)和嗜中性粒细胞百分比(N%)在细菌感染性疾病中的诊断价值。方法选取细菌感染性疾病患者272例作为研究对象,所有患者均符合感染诊断标准,且经实验室检查和微生物培养确诊。结果细菌感染总灵敏度为PCT>CRP>N%>WBC,特异度为PCT>CRP>WBC>N%。不同细菌感染后,PCT灵敏度为肺炎克雷伯杆菌>大肠埃希菌>金黄色葡萄球菌>肺炎链球菌>鲍曼不动杆菌;CRP灵敏度为肺炎链球菌>肺炎克雷伯杆菌>大肠埃希菌>金黄色葡萄球菌>鲍曼不动杆菌;WBC灵敏度为鲍曼不动杆菌>大肠埃希菌>金黄色葡萄球菌>肺炎链球菌>肺炎克雷伯杆菌;N%灵敏度为肺炎链球菌>肺炎克雷伯杆菌>鲍曼不动杆菌>大肠埃希菌>金黄色葡萄球菌。不同细菌感染后,PCT水平显示肺炎克雷伯杆菌>肺炎链球菌>大肠埃希菌>金黄色葡萄球菌>鲍曼不动杆菌;CRP水平显示肺炎克雷伯杆菌>肺炎链球菌>大肠埃希菌>金黄色葡萄球菌>鲍曼不动杆菌;WBC水平显示金黄色葡萄球菌>鲍曼不动杆菌>大肠埃希菌>肺炎克雷伯杆菌>肺炎链球菌;N%水平显示肺炎克雷伯杆菌>肺炎链球菌>鲍曼不动杆菌>金黄色葡萄球菌>大肠埃希菌。结论 PCT、CRP、WBC和N%在细菌感染性疾病中灵敏度为PCT>CRP>N%>WBC。

Objective To explore the diagnostic values of procalcitonin （PCT） , C- reactive protein （CRP）, white blood cell （WBC）, and neutrophil （N%） in bacterial infectious diseases. Methods Selected 272 patients with bacterial infectious diseases as the research object, all the patients were in accordance with diagnostic criteria of infection, and confirmed by laboratory examination and microbial cultures. Results The total sensitivity of bacterial infection was PCT 〉 CRP 〉 N% 〉 WBC, and the specificity was PCT 〉 CRP 〉 WBC 〉 N%. After different bacterial infection, klebsiella pneumonia was larger in view of PCT sensitivity than escherichia coli, followed by staphylococcus aureus, streptococcus pneumonia, and bauman acinetobacter in ranking. In view of CRP sensitivity, streptococcus pneumonia was larger than klebsiella pneumonia, followed by escherichia coli, staphylococcus aureus, and bauman acinetobacter in ranking. In respect of WBC sensitiveness, bauman acineto- bacter was larger than escherichia coli, followed by staphylococcus aureus, streptococcus pneumonia and klebsiella pneumoniae. In respect of N% sensitivity, streptococcus pneumonia was larger than klebsiella pneumonia, followed by bowman acinetobacter, escherichia coli, and staphylococcus aureus in ranking. After bacterial infection, PCT, CRP, WBC and N% were significantly higher than normal control group, and significantly higher than normal refer- ence value. After different bacterial infections, in view of the PCT level, klebsiella pneumonia was higher than streptococcus pneumonia, followed byescherichia coli, staphylococcus aureus, and bauman acinetobacter in rank- ing. In view of CRP level, klebsiella pneumonia was higher than streptococcus pneumonia, followed by escherichia coli, staphylococcal aureus and bowman acinetobacter. In view of WBC level, staphylococcus aureus was higher than bowman acinetobacter, followed by escherichia coli, klebsiella pneumonia and streptococcus pneumoniae. In view of N% level, klebsiella pneumonia was higher than streptococcus pneumonia, followed by bowman acinetobacter, staphylococcus aureus and escherichia coil Conclusion In terms of the sensitivity of PCT, CRP, WBC and NEC% to bacterial infection, the sequence is PCT 〉 CRP 〉 N% 〉 WBC.