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阿奇霉素辅助治疗侵袭性牙周炎的临床疗效研究 被引量:4

Evaluation of Curative Effect with Systemic adjunctive Azithromycin Therapy in Aggressive Periodontitis after Scaling and Root Planning
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摘要 目的通过临床干预实验,观察阿奇霉素对侵袭性牙周炎疗效的影响。方法随机选取于2012年12月至2014年2月在大连市口腔医院牙周科就诊的确诊为侵袭性牙周炎的患者24例(年龄15~34岁),随机分为两组,每组各12例,其中一组治疗后服用阿奇霉素,另外一组为对照组,即牙周基础治疗后未服用任何抗生素。分别在治疗前和治疗结束后6周检测探诊深度(PD)≥5 mm位点的PD、临床附着丧失(CAL)、龈沟出血指数(BI),比较两组之间疗效的差异。应用SPSS 13.0软件包对测量结果进行统计分析,P<0.05认为有统计学差异。结果 GAgP患者的治疗后6周的PD、CAL、BI均较治疗前有显著改善,且有统计学意义(P<0.05);口服阿奇霉素组的患者与对照组比较,PD和CAL差异有统计学意义(P<0.05),BI差异无统计学意义(P>0.05)。结论侵袭性牙周炎患者在洁治和根面平整后口服阿奇霉素可使PD和CAL显著降低。 Objective The aim of the intervention trial was to evaluate the curative effect of azithromycin in aggressive periodontitis after scaling and root planning(SRP). Methods 24 patients with aggressive periodontitis aged from 15 to 31 were chosen for the study, The patients referred to the department of periodontology of stomatology hospital of dalian from December 2012 to February 2014. They were devided into 2 groups randomly. Each group have 12 patients. One group taking azithromycin after treatment, the other one was the control group that is not taking any antibiotics after periodontal treatment. Probing depth(PD)which not less than 5 mm, clinical attachment loss(CAL), bleeding index(BI)was recorded at baseline and 6 week after initial treatment. Statistical analyses were performed using SPSS13.0. P〈0.05 was considered to be statistically significant, Results All indices of 2groups improved significant (P〈0.05) after therapy; Indices of PD and CAL of azithromycin groups showed sigaificant improvement (P〈0.05) compared with control group, but indices of BI showed no difference (/〉〉0.05) compared with control group. Conclusion Treatment with SRP plus azithromycin is more effective than SRP alone in PD reduction and CAL gain with aggressive periodontitis.
机构地区 大连市口腔医院
出处 《中国医药指南》 2018年第6期13-14,共2页 Guide of China Medicine
关键词 侵袭性牙周炎 洁治 根面平整 阿奇霉素 Aggressive periodontitis Scaling Root planing Azithromycin
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