IL-35、IL-22与广西肝癌家族聚集性的相关性研究

The relationship between IL-35,IL-22 and familial aggregation of hepatocellular carcinoma in Guangxi

目的:探讨白介素(IL)-35、IL-22与广西肝癌家族聚集性的相关性。方法:2017年3~5月选取广西肝癌高发区肝癌高发家族成员93例作为研究组,以相同生活环境、相同生活习惯、同性别、同民族、同HBV携带状况、年龄相差5岁以内作为匹配条件,选择无癌家族成员93例作为对照组。采用酶联免疫吸附试验(ELISA)法检测两组血清IL-35、IL-22水平。结果:研究组血清IL-35水平明显高于对照组(P<0.05)。两组IL-22水平比较无明显差异(P>0.05)。研究组中壮族和乙型肝炎表面抗原(HBs Ag)阴性成员的IL-35水平明显高于对照组壮族和HBs Ag阴性成员(P<0.05),而相应的IL-22水平与对照组无明显差异(P>0.05)。结论:IL-35与广西肝癌家族聚集性存在一定相关性,IL-22与广西肝癌家族聚集性无明显相关性。

Objective： To investigate the relationship between serum levels of interleukin （IL） -35, IL-22 and familial aggregation of hepatocellular carcinoma （HCC） in Guangxi, China. Methods： From March to May 2017, 93 carcinoma-free members from HCC high-incidence families （research group） and 93 healthy person from carcinoma-free families （control group） were enrolled in this study. The levels of IL-35 and IL-22 in se- rum were detected by enzyme-linked immunosorbent assay （ELISA）. Results： The IL-35 level in the research group was higher than that in the control group （P〈 0. 05）. There was no significant difference in serum IL-22 level between the two groups （P〉0. 05）. Conclusion： Serum level of IL-35 might be associated with familial aggregation of HCC, but no obvious correlation between the IL-22 level and familial aggregation of HCC in Guangxi.