原子吸收光谱法测定化学原料药中的钌

Determination of ruthenium in Aptiom (eslicarbazepine acetate) by atomic absorption spectrometry

醋酸艾司利卡西平是一种抗癫痫药物。在原料药合成中需要使用钌炭催化剂,这是一种重要的金属催化剂,广泛应用于化工及医药合成等领域中。在原料药中钌的含量限值控制是一个非常关键的指标。本文建立了石墨炉原子吸收光谱法测定原料药(醋酸艾司利卡西平)中的催化剂钌残留的分析方法。通过配制钌系列标准溶液,验证标准曲线方程和相关系数,确定该方法的相关系数均为0.998以上,钌回收率较好,在84%~92%之间。方法检出限为0.0204mg/kg,RSD值为0.365%。该方法可用于原料药(醋酸艾司利卡西平)中的催化剂钌残留的测定。

The standard curve of ruthenium series standard solutions was calibrated with correlation coefficient above 0.998.And the recoveries of the method were in the range of 84% -92% and its detection limit was 0.0204 mg/kg with RSD of 0.365% .Therefore,the established method could be applied to routine determination of ruthenium catalyst residues in Aptiom（eslicarbazepine acetate）.