TWEAK基因多态性与中国江苏地区急性心肌梗死的相关性研究

Association between TWEAK gene polymorphism and acute myocardial infarction in Jiangsu area of China

目的:探讨江苏地区急性心肌梗死与肿瘤坏死因子样凋亡微弱诱导剂(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)基因多态性rs12937543、rs4968211、rs11552708位点单核苷酸基因多态性的相关性。方法:收集本院2016-07-2017-07收住急性心肌梗死患者267例为病例组,另选取健康体检者281例为对照组,采用聚合酶链反应-限制性片段长度多态性方法检测TWEAK基因多态位点rs12937543、rs4968211、rs11552708的基因型和等位基因分布频率。结果:TWEAK基因多态性位点rs12937543基因频率在病例组与对照组中分布差异具有统计学意义(P<0.05);T等位基因能显著增加急性心肌梗死的危险,且与TWEAK血浆表达水平相关(P<0.05)。rs4968211、rs11552708位点均无统计学差异。结论:TWEAK基因多态性位点rs12937543与江苏地区急性心肌梗死存在相关性。

Objective：To investigate the association between rs12937543,rs4968211 and rs11552708 single nucleotide polymorphism in TWEAK and acute myocardial infarction in Jiangsu province.Method：A total of 261 patients with acute myocardial infarction（AMI group）and 281 healthy cases（control group）from July 2016 to July2017 in Zhongda Hospital were included.Polymerase chain reaction-restriction fragment length polymorphisms was used to identify genotypes and alleles of rs12937543,rs4968211 and rs11552708.Result：Frequencies of rs12937543 genotype and allele were statistically significant different between AMI group and control group（P0.05）.The exist of T allele increased the risk of AMI and had a correlation with the plasma level ofTWEAK（P0.05）.There was no relationship in rs4968211 and rs11552708 between AMI and control group.Conclusion：The TWEAK gene polymorphism site rs12937543 is associated with acute myocardial infarction in Jiangsu province.