原发性高血压患者自主神经功能与血清一氧化氮的相关性

The relationship between autonomic nervous function and serum nitric oxide in patients with essential hypertension

目的:探讨原发性高血压患者自主神经功能与血清一氧化氮(NO)的相关性。方法:连续纳入原发性高血压患者284例,以血清NO二分位数进行分组(NO-1组≤38.04μmol/L,NO-2组>38.04μmol/L),对所有患者行血清NO测定及24h动态心电图监测,收集血清NO值和心率变异性(HRV)的频域分析指标VLF、LF、HF、LF/HF及时域分析指标SDNN、SDANN、rMSSD、pNN50,分析血清NO与HRV之间的关系。结果:Pearson相关分析显示,血清NO与年龄、24hSBP、24hDBP、LF、LF/HF分别呈负相关(r=-0.248、-0.488、-0.368、-0.506、-0.454,均P<0.05),与HF、SDANN呈正相关(r=0.263、0.454,均P<0.05)。多元线性回归分析显示,24hSBP、HF、LF为血清NO的独立影响因素。结论:原发性高血压患者血清NO降低与收缩压升高、交感神经过度激活和副交感神经抑制有关。

Objective：To investigate the relationship between autonomic nervous function and serum nitric oxide（NO）in patients with essential hypertension.Method：A total of 284 subjects were enrolled and divided into two groups according to serum NO concentration（NO-1≤38.04μmol/L,NO-238.04μmol/L）.The value of serum NO and heart rate variability（HRV）frequency domain indexes VLF,LF,HF,LF/HF and time domain indexes SDNN,SDANN,rMSSD,pNN50 were collected.Then the association between serum NO and HRV was explored.Result：Pearson＇s correlation analysis showed that age,24 hSBP,24 hDBP and LF,LF/HF were negatively correlated with serum NO（r=-0.248,-0.488,-0.368,-0.506,-0.454 respectively,all P0.05）,while HF,SDANN were positively correlated with serum NO（r=0.263,0.454,both P0.05）.Multiple linear regression revealed that 24 hSBP,LF and HF were independent influential factors of serum NO.Conclusion：The decrease of serm NO is associated with elevated systolic blood pressure,sympathetic overdrive and parasympathetic inhibition in patients with essential hypertension.