乙肝相关肝癌患者血清肿瘤坏死因子-α、白介素-6水平测定

Serum Levels of Tumor Necrosis Factor-α and Interleukin-6 in the Liver Cancer Patients with Hepatitis B

目的探讨乙肝相关肝癌患者血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平及其临床价值。方法采用酶联免疫吸附试验检测53例乙肝相关肝癌患者和25例健康体检者血清中TNF-α、IL-6水平,并分析两者的相关性。结果乙肝相关肝癌患者血清中TNF-α、IL-6水平分别为(103.25±38.21)、(296.57±87.64)ng·L-1,均高于健康体检者的(25.67±10.23)、(19.35±9.57)ng·L-1,差异均有统计学意义(t=9.953、15.718,P均<0.001)。乙肝相关肝癌患者血清中TNF-α、IL-6水平呈正相关关系(r=0.597,P<0.001)。结论 TNF-α、IL-6在乙肝相关肝癌患者中存在过量表达,可能导致机体的免疫功能异常。

Objective To investigate the serum levels of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） in the liver cancer patients with hepatitis B and their clinical significance. Methods Enzyme linked immunosorbent assay was used to detect the serum levels of TNF-α and IL-6 in the liver cancer patients with hepatitis B, and their relationship were analyzed. Results The serum levels of TNF-α and IL-6 in the liver cancer patients with hepatitis B were respectively （103.25 ± 38.21 ） and （296.57 ±87.64）ng ·L-1, and were （25.67 ± 10.23 ） and （19.35 ±9.57）ng· L-1 in the healthy controls （t =9.953,15.718;P 〈0.001）. The serum level of TNF-α had positively related with IL-6 in the liver cancer patients with hepatitis B （ r = 0. 597, P 〈 0.001 ）. Conclusion Overexpressions of TNF-α and IL-6 are observed in the liver cancer patients with hepatitis B, they can induce the immunologic dysfunction.