人乳头瘤病毒与梅州地区客家人食管鳞癌的相关性

Relationship Between HPV and Esophageal Squamous Cell Carcinoma of the Hakkas in Meizhou

目的探讨梅州地区客家人食管鳞癌与人乳头瘤病毒(HPV)感染的关系。方法应用免疫组化方法检测梅州地区客家人食管鳞癌及食管良性肿瘤组织中HPV的表达情况。结果 HPV全部着色在细胞浆,61例梅州地区客家人食管鳞癌组织标本中HPV表达阳性24例(39.3%),32例梅州地区客家人食管良性肿瘤组织中HPV表达阳性3例(9.4%),差异有统计学意义(P<0.05)。梅州地区客家人食管鳞癌患者的HPV感染与其分化程度和淋巴结转移有关(P<0.05)。结论 HPV与梅州地区客家人食管鳞癌的发病有关,可能是其潜在的致病因素。

Objective To investigate the relationship between HPV infection and esophageal squamous cell carcinoma of the Hakkas in Meizhou. Methods Immunohistochemical method was performed to examine the HPV expression of 61 patients with esophageal squamous cell carcinoma of the Hakkas in Meizhou and 32 patients with benign esophageal tumors of the Hakkas in Meizhou. Results HPV was evident in cytoplasmic of esophageal squamous cell carcinoma cells. HPV expression positive were 24 patients （39.3%） in the 61 patients with esophageal squamous cell carcinoma of the Hakkas in Meizhou, and were 3 patients （9.4%） in the benign esophageal tumors of the Hakkas in Meizhou（ P 〈 0.05 ）. HPV infection was associated with differentiation degree and lymph node metastasis, of esophageal squamous cell carcinoma of the Hakkas in Meizhou （P 〈 0.05）. Conclusion HPV infection was a potential pathogenetic factor of esophageal squamous cell carcinoma of the Hakkas in Meizhou.