表观遗传修饰与急性髓系白血病关系的研究进展

Progress on relationship between epigenetic modification and acute myeloid leukemia

急性髓系白血病（acute myeloid leukemia,AML）是一种较为常见的疾病,主要为功能受损的造血祖细胞增殖活跃,这种改变导致血细胞分化成熟异常,由于缺乏有效治疗,患者通常在诊断的1年以内死于感染,出血以及器官浸润。

Acute myeloid leukemia（AML）is a rather common disease,which is characterized by proliferation of impaired-function hematopoietic progenitor cells.In tradition standpoint,AML had been considered a genetic-alteration disease,but more and more experimental evidence showed that epigenetic modifications would play an important role in the development and maintenance of leukemia cells.In this article,we summarized the relationship of epigenetic alterations and acute myeloid leukemia.