小剂量氯氮平治疗帕金森病合并睡眠障碍的疗效观察

Clinical efficacy of low dose clozapine in the treatment of Parkinson's disease with sleep disorder

目的观察小剂量氯氮平治疗帕金森病患者睡眠障碍的临床疗效和安全性。方法将60例患者按随机、双盲法分为治疗组和对照组各30例,治疗组给予小剂量氯氮平12.5~50mg/d,睡前服用;对照组给予艾司唑仑1~2mg/d,睡前服用。疗程均为1个月。通过Epworth嗜睡量表(ESS)、帕金森病睡眠量表(PDSS)比较2组治疗前后的疗效及观察不良反应。结果2组治疗后ESS、PDSS评分均较治疗前明显改善(P<0.05),但治疗组较对照组改善明显(P<0.05)。治疗过程中未见明显不良反应。结论小剂量氯氮平能有效改善PD患者的睡眠障碍,安全性好。

Objective To observe the clinical efficacy and safety of low dose of clozapine in the treatment of sleep disorders in patients with Parkinson＇s disease.Methods 60 cases of patients were divided into treatment group and control group,with 30 cases in each group,the treatment group was treated with clozapine at low doses（12.5-50 mg）/d before sleep;the control group was treated with estazolam before sleep.The treatment lasted for 1 month.We observed the efficacy of the two groups of patients before and after treatment by Epworth sleepiness scale（ESS）and Parkinson＇s disease Sleep Scale（PDSS）,The adverse reactions in the two groups were also recorded.Results The ESS and PDSS scores of the two groups were significantly improved than before treatment（P0.05）,but the treatment group improved significantly compared with the control group（P0.05）.There was no obvious adverse reaction during the treatment.Conclusion Low doses of clozapine can safely and effectively improve sleep disorders in PD patients.