摘要癫痫是神经系统最常见的慢性疾病之一。癫痫患者结婚率、生育率低。多囊卵巢、多囊卵巢综合症、高雄激素血症、性功能障碍等常见于女性癫痫患者(Women with epilepsy,WWE)。癫痫放电或抗癫痫药物(AEDs)影响下丘脑-垂体-卵巢轴系统调节,引起体内激素水平改变,因而WWE易患生殖内分泌疾病。文章就癫痫及AEDs对育龄期WWE生殖内分泌的影响进行综述。
1Karceski S, Morrell MJ, Carpenter D. Treatment of epilepsy in adults : expert opinion, 2005. Epilepsy Behav, 2005, 7 Suppl 1 : S1-64.
2French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs I. Treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 2004, 62: 1252-1260.
3Perucca E, Gram L, Avanzini G, et al. Antiepileptic drugs as a cause of worsening seizures. Epilepsia, 1998, 39 : 5-17.
4Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med, 2000, 342: 314-319.
5Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet, 2007, 369 : 1016-1026.
6Beghi E, Gatti G, Tonini C, et al. Adjunctive therapy versus ahernative monotherapy in patients with partial epilepsy failing on a single drug: a muhicentre, randomized, pragmatic controlled trial. Epilepsy Res, 2003, 57: 1-13.
7Kwan P, Brodie MJ. Epilepsy after the first drug fails : substitution or add-on? Seizure, 2000, 9: 464468.
8Hauser WA. Seizure disorders: the changes with age. Epilepsia, 1992, 33 Suppl 4: $6-14.
9Wallace H, Shorvon S, Tallis R. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet, 1998, 352: 1970-1973.
10Faught E. Monotherapy in adults and elderly persons. Neurology, 2007, 69 (24 Suppl 3 ) : $3-$9.
