酮病对围产期奶牛免疫功能影响研究进展

Progress on Effect of Ketosis on Immune Functions in Perinatal Cows

高酮血症和高游离脂肪酸血症是酮病的主要病理学特征。酮病的发生与动物机体发生氧化应激密切相关,研究表明,高酮血症和高NEFA血症影响动物体淋巴细胞、白细胞和中性粒细胞的数量及功能,对外周血免疫球蛋白G和部分细胞因子也有相应影响,从而酮病的发生降低了奶牛免疫功能,使患酮病的奶牛发生乳房炎、胎衣不下、子宫内膜炎等其他围产期疾病的风险增加,严重降低了奶牛生产性能和繁殖性能,给奶牛养殖业造成巨大经济损失。论文主要综述了奶牛酮病对奶牛免疫功能的影响及其机制,为深入研究酮病与其他围产期疾病之间的关系提供依据。

Hypernatremia and high free fatty acid （NEFA） hyperlipidemia are the main pathologic features of ketosis.The occurrence of ketosis is closely related to the oxidative stress in animals.Studies have shown that hyperaldosteronism and high NEFA hyperlipidemia affect the numbers and functions of lymphocytes, white blood cells and neutrophils in animals, so that the occurrence of ketosis reduces the immune function of dairy cows, and the risks of mastitis, placenta retention, endometritis and other perinatal disease in- crease, making a serious reduction in cow production performance and reproductive performance and huge economic losses in dairy industry. This paper reviewed the effects of dairy cow ketone disease on the im- mune functions of dairy cows and its mechanism, and provided the basis for further study on the relation- ship between ketosis and other perinatal diseases.