甲状腺乳头状癌患者促甲状腺激素表达水平及与发病率关系研究

Study of Thyroid Hormone Expression in Thyroid Papillary Carcinoma Patients and Its Relationship with Morbidity

目的探讨促甲状腺激素(TSH)水平在甲状腺乳头状癌(PTC)患者中的表达及其临床意义。方法选取2015年2月至2016年5月我院收治的甲状腺结节患者60例,所有患者均行甲状腺结节切除术,根据术后病理结果分为良性结节组(n=24)和PTC组(n=36)。对比分析两组患者血清TSH水平,并分析不同TSH水平患者良性结节与PTC发病率的差异。结果 PTC组的TSH水平为(2.23±0.37)μIU/ml,高于良性结节组的(1.56±0.28)μIU/ml,差异具有统计学意义(P<0.05)。随着TSH水平的升高,良性结节的发病率逐渐下降,PTC的发病率逐渐升高,差异具有统计学意义(P<0.05)。结论血清中TSH水平与PTC的发病有一定关系,TSH水平越高,PTC发病率越高,TSH水平可作为PTC早期诊断的有效参考指标之一。

Objective To investigate the expression of thyroid stimulating hormone（TSH）in thyroid papillary carcinoma（PTC）and its clinical significance.Methods Totally 60 patients with thyroid nodules admitted in our hospital from February 2015 to May 2016 were enrolled in this study.Thyroidectomy was performed in all patients.According to the postoperative pathological findings,they were divided into benign nodules（n=24）and PTC group（n=36）.The levels of serum TSH were compared between the two groups,and the differences of benign nodules and PTC in patients with different TSH levels were analyzed.Results The TSH level in PTC group was（2.23±0.37）μIU/ml,which was significantly higher than that in benign nodule group（1.56±0.28）μIU/ml.The difference was statistically significant（P〈0.05）.With the increase of TSH level,the incidence of benign nodules gradually decreased,and the incidence of PTC gradually increased.The difference was statistically significant（P〈0.05）.Conclusion The serum level of TSH is related to the onset of PTC.The higher the level of TSH,the higher the incidence of PTC.The level of TSH can be used as one of the effective reference indexes for the early diagnosis of PTC.