白鲜皮化学成分分离与鉴定

Isolation and Identification of Chemical Constituents from the Root of Dictamnus dasycarpus

白鲜皮乙醇提取物乙酸乙酯萃取层采用反复硅胶柱色谱、凝胶柱色谱、制备HPLC分离得到单体化合物,通过光谱方法对其化学成分进行结构鉴定。从白鲜皮乙醇提取物的乙酸乙酯萃取层中分离得到6个化合物,分别鉴定为3-醛基吲哚(1),5-羟基-2-羟甲基吡啶(2),白鲜碱(3),大叶桉亭(4)邻苯二甲酸二丁酯(5),β-谷甾醇(6)。其中化合物1及化合物2为白鲜皮种内首次分离。

Dictamnus dasycapus was extracted using ethanol and ethyl acetate, isolated by repeated silica gel column chromatography, gel column chromatography, and prepared by HPLC and identified by spectral methods. Six compounds were isolated from the barks of Dictamnus dasycapus. The structures were identified as 1H -Indole -3 - carboxaldehyde （ 1 ）, 5 - hydroxyl - 2 - hydroxyl methyl pyridine （ 2 ）, dictamnine （ 3 ）, robustine （ 4 ）, dibutyl phthalate （5）, β - sitosterol （6）. The compound （ 1 ） and （2） were the first isolated from this plant.