右美托咪定与芬太尼对无痛人流的临床安全性及效果观察

Clinical Efficacy and Safety of Dexmedetomidine and Fentanyl for Painless Patients

目的探讨右美托咪定与芬太尼对无痛人流的临床安全性和效果分析观察。方法选取自2015年2月至2016年2月于大连市中心医院手术室接受无痛人流患者60例,试验组与对照组均应用信封法随机分组,对照组30例,应用芬太尼联合丙泊酚麻醉,试验组30例,应用右美托咪定联合丙泊酚麻醉方案,观察两组患者手术时间、苏醒时间、丙泊酚总剂量、低血压、呼吸抑制、心动过缓及恶心呕吐情况。结果试验组手术及苏醒时间、丙泊酚总剂量、不良反应发生情况均低于对照组,有统计学差异(P<0.05)。结论右美托咪定联合丙泊酚可明显提高麻醉效果,降低丙泊酚用量,缩短手术及苏醒时间,减轻不良反应发生率,安全性较高,临床麻醉效果优异,值得临床推广。

Objective To investigate the clinical safety and efficacy of dexmedetomide and fentanyl in painless abortion. Methods From February 2015 to February 2016, 60 patients with painless abortion in the operating room of Dalian Central Hospital were randomly divided into control group（n=30） and control group（n=30）. Fentanyl Combined with propofol anesthesia, the experimental group of 30 patients, the application of dexmedetomidine combined with propofol anesthesia program to observe the two groups of patients operating time, wake time, total propofol dose, hypotension, respiratory depression, bradycardia and Nausea and vomiting. Results The total dose of propofol and the incidence of adverse reactions were significantly lower in the experimental group than in the control group（P〈0.05）. Conclusion Dexmedetomide combined with propofol can significantly increase the anesthesia effect, reduce the dosage of propofol, shorten the operation and recovery time, reduce the incidence of adverse reactions, safety is high, clinical anesthesia is excellent, worthy of clinical popularization.