急性脑梗死后早期抑郁与梗死部位、IL-18、UA、HCY相关性研究

Correlative Analysis of Early Post-stroke Depression,Location of Brain Infarction,Serum Level of IL-18,HCY and UA

目的探讨急性脑梗死部位、外周血清白细胞介素-18(IL-18)、尿酸(UA)、同型半胱氨酸(HCY)与急性脑梗死后早期抑郁的相关性。方法患者发病后14 d使用医院焦虑抑郁量表(HAD)和汉密尔顿抑郁量表(HAMD-17)筛查急性脑梗死后抑郁患者35例设为试验组,根据抑郁程度的不同分为轻、中、重3组,无抑郁的急性脑梗死患者35例设为对照组,采用酶联免疫吸附法(ELISA)检测患者血清IL-18,全自动生化仪检测UA、HCY。结果试验组血清IL-18水平明显高于对照组(P<0.05);血清IL-18水平与试验组抑郁程度成正相关(r=0.70,P<0.05),两组脑梗死部位、UA、HCY比较,差异无统计学意义(P>0.05)。结论急性脑梗死后早期抑郁与血清IL-18水平呈正相关性,与梗死部位、UA、HCY无关。

Objective To explore the correlation of early post-stroke depression, location of brain infarction ,serum level of interleukin-18 （ IL-18）, homocysteine（HCY） and Serum UricAcid （UA）.Methods For patients with acute cerebral infarction diagnosed as acute cerebral infarc- tion,35 patients with post-acute cerebral infarction were screened with the Hospital Anxiety and Depression Scale （HAD） and the Hamilton Depression Scale （HAMD-17） in the second week of onset. In the experiment group,35 patients with acute cerebral infarction were divided into mild,moderate and severe groups according to the degree of depression.The levels of IL- l8 in peripheral serum were detected by enzyme-linked immunosorbent assay （ELISA）.The UA and HCY concentrations were measured by automatic biochemical analyzer.Results IL-18 in the experiment group was significantly higher than that in the control group （P〈0.05）.The level of serum IL-18 was positively correlated with the degree of depression in the experimental group （r=0.70,P〈0.05）.There was statistical difference between serum level of interleukin-18 （IL-18）, HCY and UA （P〉0.05）.Conclusion PSD patients＇ expression of I L-18 was positively related to the dearee of their deoression,but not related to UA and HCY.