纤维支气管镜刷检液基细胞学检查在肺癌诊断中的价值分析

Analysis on value of fiber bronchoscope brush liquid based cytology in diagnosing lung cancer

目的评估纤维支气管镜刷检液基细胞学检查在肺癌诊断及分型诊断中的价值。方法回顾性分析肺癌患者817例,所有患者进行纤维支气管镜刷检液基细胞学检查和组织病理学检查,对二者结果进行比较分析。结果纤维支气管镜刷检液基细胞学诊断肺癌368例,鳞状细胞癌、腺癌和小细胞癌分别177例、84例和68例,单独诊断肺癌15例,灵敏度为44.01%,特异度为94.40%,阳性预测值为95.92%,阴性预测值为36.04%,Kappa值为0.250,与组织病理学比较差异有统计学意义(P<0.01)。结论纤维支气管镜刷检液基细胞学检查是特异性较高的肺癌诊断方法。

Objective To evaluate the value of fiber bronchoscope brush liquid based cytology in diagnosis and classification diagnosis of lung cancer. Methods Eigh hundreds and seventeen cases of lung cancer were retrospectively analyzed. All cases conducted the fiber bronchoscopy brush liquid based cytology exmination and histopathological examination. Then their results were compared. Results Three hundreds and sixty-eight casesof lung cancer were diagnosed by fiber bronchoscopy brush liquid based cytology,invluding 177 cases of squamous cell carcinoma,84 cases of adenocarcinoma and 68 cases of small cell carcinoma,and 15 cases were separately diagnosed as lung cancer. The sensitivity of was 44.01 %, specifity rate was 94.40%, positive predictive value was 95.92% ,negative predictive value was 36.04%, and the Kappa value was 0. 250, there was statistically significant difference compared with the histopathological examination （P〈0.01）. Conclusion Fiber bronchoscopy brush liquid based cytology examination is a high specificity method to diagnose lung cancer.