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对于未知来源个体进行族群推断的自动分析系统 被引量：14

DNA Ancestry Analyzer: an Automatic Program for Ancestry Inference of Unknown Individuals
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摘要 建立一种基于概率算法、聚类分析和主成分分析的DNA族群推断系统(DNA Ancestry Analyzer Version1.0,简称DAA v1.0),用于对未知来源个体进行族群推断。DAA v1.0基础部分用Python语言、R语言、C语言编写;前端部分用node.js语言、HTML语言、css语言编写。DAA v1.0可对未知来源个体的族群进行推断,与已有分析方法相比,结果的一致性为100%,运算效率提升了600%。该系统可界面化、自动化地计算DNA来源人的群体匹配概率和似然比值、群体成分,绘制群体归类图,在人类遗传学、法医遗传学等领域有重要的应用价值。 The DNA Ancestry Analyzer Version 1.0, or DAA v1.0, was established based on the probability algorithm, clustering analysis and principal component analysis to infer ancestry for unknown individuals. The basic part of DAA v1.0 was written in Python, R and C; and the front part was written in node.js, HTML, and css. DAA vl.0 can estimate continental ancestry components of unknown individuals and populations. Compared with the previous analysis method, the consistency of DAA v1.0 is 100%, and the efficien- cy is improved by about 600%. It can calculate the population assignment match probability （AMP）, likelihood ratio （LR）, population ancestry component and draw the figure of classification of unknown individuals auto- matically, and has important practical values in the field of human ~enetics and forensic genetics.
作者 刘京 李盛 江丽 赵蕾 赵雯婷 丰蕾 刘海渤 季安全 李彩霞
机构地区 公安部物证鉴定中心北京市现场物证检验工程技术研究中心现场物证溯源技术国家工程实验室 新疆生产建设兵团公安局
出处 《生命科学研究》 CAS CSCD 2018年第1期3-7,41,共6页 Life Science Research
基金 国家重点研发计划(2017YFC0803501) 国家科技资源共享服务平台计划项目(YCZYPT[2017]01-3) 公安科技成果推广引导计划(2016TGYDGAES14) 中央公益类基本科研业务费专项资金项目(2016JB039 2017JB025)
关键词 法医遗传学 族群推断 自动分析系统 DNA族群推断系统(DAAv1.0) 生物信息学 forensic genetics ancestry inference automatic analyzer DNA Ancestry Analyzer Version 1.0（DAA v1.0） bioinformatics
分类号 Q811.4 [生物学—生物工程] D919.2 [医药卫生—法医学]
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生命科学研究
2018年 第1期

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