肾康注射液结合前列地尔治疗慢性肾衰竭的临床疗效观察

Observation on clinical efficacy of Shenkang injection combined with alprostadil in the treatment of chronic renal failure

目的探究观察肾康注射液结合前列地尔治疗慢性肾衰竭的临床疗效。方法 92例慢性肾衰竭患者,随机分为观察组和对照组,各46例。对照组行前列地尔治疗,观察组行肾康注射液结合前列地尔治疗,比较两组患者治疗效果及治疗前后肾功能指标水平。结果观察组治疗总有效率为97.83%,明显高于对照组的84.78%,差异具有统计学意义(χ~2=4.929,P<0.05);治疗后,观察组血肌酐(SCr)、24 h尿蛋白低于对照组,内生肌酐清除率(Ccr)高于对照组,差异具有统计学意义(t=4.799、6.654、6.358,P<0.05)。结论肾康注射液结合前列地尔治疗慢性肾衰竭效果明显,能有效改善患者肾功能指标,且用药更为安全有效。

Objective To investigate the clinical efficacy of Shenkang injection combined with prostadil in the treatment of chronic renal failure.Methods A total of 92 patients with chronic renal failure were randomly divided into observation group and control group,with 46 cases in each group.The control group was treated with alprostadil.Comparison were made on treatment effect and renal function level before and after treatment between the two groups.Results The observation group had obviously higher total treatment effective rate as 97.83% than 84.78% in the control group,and the difference was statistically significant（χ~2=4.929,P〈0.05）.After treatment,the observation group had lower serum creatinine（SCr） and 24 h urine protein than the control group,and higher endogenous creatinine clearance（Ccr） than than the control group.Their difference was statistically significant（t=4.799,6.654,6.358,P〈0.05）.Conclusion Combination of Shenkang injection and alprostadil shows obvious effect in treating chronic renal failure.It can effectively improve the renal function indexes of patients,and it is more safe and effective.