酞菁配合物的合成及在肿瘤诊断与治疗中的研究进展

Synthesis and biomedical applications of phthalocyanine complexes

由于酞菁(Pc)配合物具有大的共轭体系,在催化、光电转换以及生物医学领域均具有广泛的应用.Pc配合物的合成主要包括:插入配位合成方法、直接取代合成法、模板反应合成法.Pc配合物在肿瘤诊断与治疗领域的应用主要包括光声成像(PAI)、磁共振成像(MRI)、光动力治疗(PDT)以及光热治疗(PTT)等.综述了Pc配合物的合成和在肿瘤诊断与治疗领域的最新研究进展.

Because of its large conjugated system,phthalocyanine complexes have been widely used in catalysis,photoelectric conversion,and biomedicine. Phthalocyanine complexes can be synthesized by many methods such as coordination insertion method,direct substitution method,and template reaction method. The applications of phthalocyanine complexes have been reported in tumor diagnosis and treatment mainly including photoacoustic imaging（PAI）,magnetic resonance imaging（MRI）,photodynamic therapy（PDT）,and photothermal therapy（PTT）. Here,the recent advances in synthesis and biomedical applications of phthalocyannine complexes were reviewed.