阿托伐他汀钙分散片联合血塞通注射液对急性脑梗死患者血脂、血液流变学及神经功能的影响

Effect of Atorvastatin calcium dispersible tablet combined with Xuesaitong injection on blood lipid,hemorheology and neurological function in patients with acute cerebral infarction

目的观察阿托伐他汀钙分散片联合血塞通注射液对急性脑梗死患者血脂、血液流变学及神经功能的影响。方法将112例急性脑梗死患者随机分为2组。对照组56例予阿托伐他汀钙分散片治疗;治疗组56例予阿托伐他汀钙分散片联合血塞通注射液治疗。2组疗程均为14 d。观察2组治疗前后血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]变化,血液流变学指标[血浆黏度、全血黏度(低切)、全血黏度(高切)、红细胞最大聚集指数、红细胞比容]变化,比较2组治疗前后美国国立卫生院神经功能缺损评分(NIHSS)、日常生活活动能力量表评分(ADL)变化,比较2组疗效及不良反应情况。结果 2组治疗后TC、TG、LDL-C均较本组治疗前降低(P<0.05),HDLC均较本组治疗前升高(P<0.05);治疗后治疗组TC、TG、LDL-C均低于对照组(P<0.05),HDL-C高于对照组(P<0.05)。2组治疗后血浆黏度、全血黏度(低切)、全血黏度(高切)、红细胞最大聚集指数、红细胞比容均较本组治疗前降低(P<0.05);治疗后治疗组血浆黏度、全血黏度(低切)、全血黏度(高切)、红细胞最大聚集指数、红细胞比容均低于对照组(P<0.05)。2组治疗后NIHSS评分均较本组治疗前降低(P<0.05),ADL评分均较本组治疗前升高(P<0.05);治疗后治疗组NIHSS评分低于对照组(P<0.05),ADL评分高于对照组(P<0.05)。治疗组总有效率98.2%,对照组总有效率87.5%,治疗组疗效优于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论阿托伐他汀钙分散片联合血塞通注射液治疗急性脑梗死疗效确切,可明显改善患者血脂、血液流变学指标及神经功能,安全性高。

Objective To observe the effects of Atorvastatin calcium dispersible tablet combined with Xuesaitong injection on blood lipid,hemorheology and neurological function in patients with acute cerebral infarction.Methods 112 patients with acute cerebral infarction were randomly divided into two groups.56 cases in control group were treated by Atorvastatin calcium dispersible tablet,56 cases in treatment group were treated by Atorvastatin calcium dispersible tablet combined with Xuesaitong injection.The treatment course was 14 d in two groups.The changes of blood lipid indexes including total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C),the hemorheology indexes including plasma viscosity,whole blood viscosity(low shear),whole blood viscosity(high shear),erythrocyte maximal aggregation index and hematocrit value,the score of National Institutes of Health Stroke Scale(NIHSS) and Activity of Daily Living(ADL) before and after treatment were compared in two groups.The curative effects and adverce reactions were compared between two groups.Results The TC,TG,LDL-C after treatment were reduced in two groups(P < 0.05),and HDL-C increased(P < 0.05).The TC,TG,LDL-C after treatment in treatment group were lower than that in control group(P < 0.05),and HDL-C was higher(P < 0.05).The plasma viscosity,whole blood viscosity(low shear),whole blood viscosity(high shear),erythrocyte maximal aggregation index and hematocrit value after treatment were reduced in two groups(P < 0.05),and which in treatment group were lower than that in control group(P < 0.05).The score of NIHSS after treatment were reduced in two groups(P < 0.05),and the score of ADL increased in two groups(P < 0.05).The score of NIHSS after treatment in treatment group were lower than that in control group(P < 0.05),and the score of ADL was higher(P< 0.05).There were statistical differences on the total effective rate between the treatment group(98.2%) and the control group(87.5%),and the clinical effects in treatment group was superior to that in control group(P < 0.05).There was no statistical difference on the incidence of adverse events between two groups(P > 0.05).Conclusion Atorvastatin calcium combined with Xuesaitong injection are effective drugs in clinical treatment for acute cerebral infarction,which can significantly improve the blood lipid and hemorheology indexes of patients,and improve neurological function with high safety.