银屑病与冠状动脉粥样硬化

Association Between Psoriasis and Coronary Artery Atherosclerosis

银屑病是一种皮肤的慢性炎症性疾病,与增高的心肌梗死发生风险密切相关。早期对银屑病患者进行心血管风险预测并优化管理对于改善其预后具有重大意义,现综述银屑病患者发生冠心病事件的风险、银屑病患者冠状动脉粥样硬化的亚临床表现、银屑病患者冠状动脉粥样硬化发生机制以及生物治疗对冠状动脉粥样硬化进展的影响等研究进展。

Psoriasis is a chronic inf lammatory disease,which not only has skin manifestation but also has a close relat ionship with increased risk of myocardial infarction. Early cardiovascular evaluation,risk prediction,and optimal management of patients with psoriasis are of great importance for improvement of their long-term clinical outcomes. The paper reviewed the increased risk of coronary events, subclinical manifestations of coronary arterial involvement, the mechanism of development of atherosclerosis, and the effect of biologic treatment on the progression of coronary artery atherosclerosis in patients with psoriasis.