一种新型钙调蛋白抑制剂合成研究

Synthesis of a new calcineurin inhibitor

以3,4-二甲氧基苯酚为起始原料,经取代、环合、酯还原、脱保护等反应得到新型的钙调蛋白抑制剂3-{2-[4-(3-氯-2-甲基苯)-1-哌嗪基]乙基}-5,6-二甲氧基-1-(4-咪唑甲基)-1 H-吲唑二盐酸化合物,其结构经核磁共振氢谱(1 H NMR)、核磁共振碳谱(^(13) C NMR)、电喷雾离子化质谱(ESI-MS)和高分辨质谱(HRMS)的确证和表征.

The important calcineurin inhibitor,3-{2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl}-5,6-dimethoxy-1-(4-imidazolylmethyl)-1 H-indazole,have been synthesized by the reaction of substitution,cyclization,reduction and deprotection,using 3,4-dimethoxyphenol as the starting material.The structure was confirmed and characterized by nuclear magnetic resonance hydrogen spectrum(1 H NMR),nuclear magentic resonance carbon spectrum(13 C NMR),high resolation mass spetrometry(HRMS)and electrosparay ioniza mass spectrometry(ESI-MS).