我国综合医院患者抑郁焦虑障碍患病率的Meta分析

Meta-analysis on the prevalence of depressive and/or anxiety disorder in general hospitals in China

目的系统评价我国综合医院患者抑郁焦虑障碍患病率,为更准确地评估综合医院焦虑抑郁患病情况提供参考。方法以"综合医院""抑郁""焦虑""depression""anxiety""general hospitals""China"为检索词,分别检索Pub Med、中国期刊全文数据库(CNKI)、中国科技期刊数据库(维普,VIP)和万方数据库收录的有关我国综合医院患者焦虑抑郁患病率的文献,并对其进行筛选和质量评价,采用Meta Analyst3.13统计合并效应量,并对患者来源、诊断工具进行亚组分析。结果共纳入文献22篇,总样本51 626例,抑郁、焦虑、抑郁焦虑共病患病率分别为13.6%(95%CI:11.3%~16.4%)、8.1%(95%CI:6.3%~10.4%)、5.2%(95%CI:3.6%~5.7%)。亚组分析显示,门诊抑郁障碍患病率14.0%(95%CI:11.3%~17.3%)高于住院患病率10.2%(95%CI:6.7%~15.1%);不同的诊断标准,抑郁障碍患病率不同,MINI为16.2%(95%CI:13.5%~19.4%),高于SCID的8.8%(95%CI:5.5%~13.6%)。敏感性分析显示,高质量文献合并后与总的合并值接近。结论我国综合医院患者抑郁焦虑障碍患病率高。

Objective To evaluate the prevalence of depression and anxiety disorder in general hospitals in China,and to provide basis for more accurate assessments of the situation of anxiety and depression in general hospitals. Methods Pub Med,China Journal Full Text Database( CNKI),Chinese scientific journal database( VIP) and Wanfang database were systematically searched with the keywords including " general hospitals" " depression" " anxiety" and " China" for the prevalence of anxiety and depression in general hospitals. All the literatures were screened and evaluated,and Meta Analyst3. 13 was used to analyze the combined effect and subgroup analysis. Results A total of 22 articles were included in the study,with a total sample of 51 626 patients. The prevalence of depression,anxiety,depression and anxiety were 13. 6%( 95% CI: 11. 3% ~ 16. 4%),8. 1%( 95% CI: 6. 3% ~ 10. 4%) and 5. 2%( 95% CI: 3. 6% ~ 5. 7%),respectively. Subgroup analysis showed that the 14. 0% prevalence rate of depressive disorder in outpatients( 95% CI: 11. 3% ~ 17. 3%) was higher than that of inpatients 10. 2%( 95% CI: 6. 7% ~ 15. 1%). In different diagnostic criteria,depressive disorder using MINI prevalence rate 16. 2%( 95% CI: 13. 5% ~ 19. 4%) was higher than that of SCID 8. 8%( 95% CI: 5. 5% ~ 13. 6%). Sensitivity analysis showed that the combined effect of high quality study was similar to that of the total.Conclusion The prevalence rate of depression and anxiety disorders in general hospitals in our country is high.