高压氧对多种疾病引起睡眠障碍的疗效观察

Observation on the therapeutic effects of hyperbaric oxygen on sleep disorders induced by different diseases

目的 观察高压氧对不同疾病引起睡眠障碍的治疗效果.方法 选择经住院治疗的突发感音神经性耳聋患者55例,脑卒中、颅脑外伤患者63例.按照患者是否经高压氧（hyperbaric oxygen,HBO）治疗分为高压氧治疗组和常规治疗组,2组患者用药及其他治疗方法相同;HBO治疗组患者每日治疗1次,10次为1个疗程,连续治疗1个疗程后对HBO治疗组和常规治疗组患者采用匹兹堡睡眠质量指数（PSQI）进行睡眠测评.结果 突发感音神经性耳聋及脑卒中、脑外伤患者2组治疗后睡眠质量均优于治疗前（P〈0.05）,高压氧治疗组感音神经性耳聋治疗后睡眠效率、睡眠障碍、日间功能及对催眠药物的需求（8.93±2.29）均优于常规治疗组（11.26±2.35）,差异有统计学意义（P〈0.05）;脑卒中、脑外伤患者经HBO治疗后除日间功能无明显改善,其余睡眠指数总评分（11.21±1.76）均明显优于常规治疗组（13.56±1.30）,差异有统计学意义（P〈0.05）.结论 高压氧对突发感音神经性耳聋、脑卒中、颅脑外伤引起的睡眠障碍有一定的改善作用.

Objective To observe the therapeutic effects of hyperbaric oxygen （ HBO） on sleep disorders induced by different diseases , so as to provide evidence for diagnosis and treatment of such disorders . Methods Fifty-five patients with sudden inductive neural hearing loss and 63 patients with stroke and traumatic brain injury who received treatment in the hospital were recruited as research subjects .In accordance with treatment methods, the patients were divided into the HBO group and the routine treatment group or the control group.The patients of the 2 groups were given the same drug treatment , except that the patients of the HBO group received HBO therapy, one session a day.After one course of treatment, sleep quality in the patients of the 2 groups were evaluated by Pittsburgh sleep quality index （PSQI）.Results T-test revealed that sleep quality of the patients with sudden inductive neural hearing loss , stroke and traumatic brain injury in the 2 groups after therapy was all superior to that before therapy （P 〈0.05）.At the same time, 2 independent sample t-test indicated that scores of sleep efficiency , sleep disorder, daytime function and demand for hypnotic drug in the patients with inductive neural hearing loss after HBO treatment （8.93 ±2.29）were all superior to those of the control group patients （11.26 ±2.35）, and statistical significance could be seen when comparisons were made between the patients of the 2 groups（P 〈0.05）.Following HBO therapy, the patients with stroke and traumatic brain injury after HBO treatment showed little improvement in daytime function , however, other scores （11.21 ±1.76） were all superior to those of the control group （13.56 ±1.30）, also with statistical significance（P 〈0.05）.Conclusions HBO could improve sleep disturbance induced by sudden inductive neural hearing loss, stroke and traumatic brain injury.