神经导航引导下硬通道多靶点治疗基底节高血压脑出血

Clinical effect of neuronavigation-guided multi-target hard-channel technique in treatment of hypertensive basal ganglia hemorrhage

目的探讨神经导航引导下硬通道多靶点治疗基底节区高血压脑出血的疗效。方法治疗组根据神经导航确定穿刺部位、角度及深度,应用硬通道多靶点技术微创治疗,对照组采用经外侧裂岛叶入路显微手术治疗,两组患者各40例,观察对比两组疗效差异。结果两组患者术后6小时血肿清除率、平均手术时间、3天后肺部感染发生率、1月后GOS评分等级差异均有统计学意义(P﹤0.05),术后48小时左右血肿清除率及再出血率差异不明显,无统计学意义(P﹥0.05)。结论神经导航引导下硬通道多靶点治疗基底节高血压脑出血可降低死亡率及术后肺部感染等并发症,疗效满意,值得临床推广应用。

Objective To investigate the clinical effect of neuronavigation-guided multi-target hard-channel technique in the treatment of hypertensive basal ganglia hemorrhage.Methods A total of 80 patients were divided into treatment group and control group,with 40 patients in each group. For the patients in the treatment group,neuronavigation was used to determine the site,angle,and depth of puncture,and the multi-target hard-channel technique was used for minimally invasive therapy; for those in the control group,microsurgery was given via the lateral fissure-insular approach. The clinical outcome was compared between the two groups. Results There were significant differences between the two groups in hematoma clearance rate at 6 hours after surgery,mean time of operation,incidence rate of pulmonary infection at 3 days after surgery,and Glasgow Outcome Scale score at 1 month after surgery（ P〈0.05）; however,there were no significant differences in hematoma clearance rate and rebleeding rate between the two groups at about 48 hours after surgery（ P〈0.05）.Conclusions In the treatment of hypertensive basal ganglia hemorrhage,the neuronavigation-guided multi-target hard-channel technique has a good clinical effect and can reduce mortality rate and postoperative pulmonary infection. Therefore,it holds promise for clinical application.