中医药治疗鼻咽癌放化疗后不良反应临床研究

Clinical Research of Adverse Reactions of Traditional Chinese Medicine in the Treatment of Nasopharyngeal Carcinoma after Radiotherapy and Chemotherapy

目的观察分析中医药治疗放化疗后鼻咽癌患者不良反应的临床疗效。方法对我院就诊的确诊鼻咽癌并行同期放化疗患者中,选取符合入组标准的患者共200例,采用随机数字表分组单盲方法将其分为2组,对照组(同期放化疗)100例,研究组(中药方剂配合同期放化疗)100例。结果 2组放化疗后的毒性反应无统计学意义(x^2=0.084,P=0.235),但研究组口腔黏膜反应明显优于对照组(x^2=0.255,P=0.000),唾液腺损伤程度低于对照组(x^2=0.205,P=0.000),差异有统计学意义。结论中医药配合治疗鼻咽癌同步放化疗能有效改善患者胃肠道及口腔黏膜反应、唾液腺损伤等不良反应,并能有效提高患者生活质量。

Objective： To observe and analyze the effect of traditional Chinese medicine in the treatment of nasopharyngeal carcinoma after radiotherapy and chemotherapy. Methods： A total of 200 patients with concurrent nasopharyngeal carcinoma diagnosed with nasopharyngeal carcinoma in our hospital were enrolled in this study. 200 patients who met the inclusion criteria were randomly divided into two groups according to the single-blind random number table.100 cases in the control group, the study group, 100 cases in the treatment group in which traditional Chinese medicine was used. Results： The toxicity of radiotherapy and chemotherapy in the two groups had no significant difference（χ~2=0.084, P=0.235）. However, the oral mucosal response in the study group was significantly better than that in the control group（χ~2=0.255, P=0.000） The control group（χ~2=0.205, P=0.000）, the difference was statistically significant.Conclusion： Chinese medicine combined with concurrent radiotherapy and chemotherapy for nasopharyngeal carcinoma can effectively improve gastrointestinal and oral mucosal reactions, salivary gland injury and other adverse reactions, and can effectively improve the quality of life of patients.