普米克令舒联合万托林治疗哮喘患儿的疗效及对炎性因子的影响

Effect of ventolin combined with pulmicort in the treatment of children with asthma and its influence on inflammatory cytokines

目的 探讨普米克令舒联合万托林治疗哮喘患儿的疗效及对炎性因子的影响.方法 选择哮喘患儿100例为研究对象,采用随机数字表法将患儿分为观察组（50例）和对照组（50例）.对照组采取普米克令舒治疗,观察组在对照组基础上给予0.5％万托林,疗程3～5 d.观察比较两组最大呼吸量（VC）、用力肺活量（FVC）、呼气峰流速（PEFC）、症状缓解时间、血清IL-17和转化生长因子（TGF）以及不良反应.结果 观察组治疗后VC、FVC、PEFC明显优于对照组,差异均有统计学意义（t=2.412、9.806、3.922,均P〈0.05）;观察组治疗后的临床症状缓解时间明显优于对照组,差异均有统计学意义（t=5.182、4.576、4.166、5.761,均P〈0.05）;观察组的不良反应发生率为16.00％,与对照组的18.00％比较差异无统计学意义（χ2=2.153,P=0.117）;观察组炎性因子IL-17、TGF水平低于对照组,差异均有统计学意义（t=8.234、25.075,均P〈0.05）.结论 普米克令舒联合万托林治疗哮喘患儿可有效缓解患儿临床症状,减少体内炎性因子,提高患儿肺功能,因此值得在临床上推广应用.

 Objective To study the effect of ventolin combined with pulmicort in the treatment of children with asthma and its influence on inflammatory cytokines .Methods 100 children with asthma were randomly divided into observation group（50 cases） and control group（50 cases） according to the digital table.The control group was given pulmicort treatment ,the observation group was given 0.5% ventolin combined with pulmicort .The course of treatment was 3-5 days.The remission time,the levels of inflammatory cytokines （IL-17 and TGF ） and adverse reactions were compared between the two groups .Results After treatment,the VC,FVC and PEFC of the observation group were significantly better than those of the control group ,the differences were statistically significant （t=2.412, 9.806,3.922,all P〈0.05）.The remission time of clinical symptoms of the observation group was better than those of the control group（t=5.182,4.576,4.166,5.761,all P〈0.05 ）.There was no statistically significant difference in the side effects between the two groups （18.00%vs.16.00%,χ2 =2.153,P〉0.05）.The levels of IL-6 and TGF in the observation group were lower than those in the control group （t =8.234,25.075,all P 〈0.05）. Conclusion Ventolin combined with pulmicort in the treatment of children with asthma can effectively relieve clinical symptoms,reduce the inflammatory cytokines ,improve pulmonary function ,so it is worthy of further clinical application .