他克莫司软膏联合奥硝唑、克拉霉素治疗酒渣鼻合并面部激素依赖性皮炎的疗效观察

Observation of tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea with facial hormone dependent dermatitis

目的 观察他克莫司软膏联合奥硝唑、克拉霉素治疗酒渣鼻合并面部激素依赖性皮炎的疗效及安全性.方法 选取酒渣鼻合并面部激素依赖性皮炎的患者80例为研究对象,采用随机数字表法分为观察组和对照组,每组40例,观察组采用0.1％他克莫司软膏外涂,每天2次,共8周,同时服用奥硝唑、克拉霉素4周;对照组0.1％他克莫司软膏每天2次外涂,共8周,疗程结束时比较两组的疗效,疗程结束4周后比较两组的反跳情况.结果 观察组总有效率为92.5％,对照组总有效率为67.5％,两组差异有统计学意义（χ2=7.68,P〈0.05）.治疗前观察组症状总评分为（19.93±0.76）分,对照组为（19.89±4.07）分,两组差异无统计学意义（P〉0.05）.治疗后治疗组症状总评分为（2.45±3.78）分、对照组为（5.16±2.76）分,两组差异有统计学意义（P〈0.05）.治疗组反跳率为7.50％,对照组反跳率为31.58％,两组差异有统计学意义（χ2=5.97,P〈0.05）.结论 他克莫司软膏联合奥硝唑、克拉霉素治疗酒渣鼻合并面部激素依赖性皮炎疗效及安全性满意,综合治疗优于单一治疗.

 Objective To observe the efficacy and safety of tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea with facial hormone dependent dermatitis .Methods A total of 80 cases with rosacea complicated with facial hormone dependent dermatitis were selected , and they were randomly divided into observation group and control group according to the digital table ,40 cases in each group .The observation group was treated with 0.1% tacrolimus ointment besmear outside 2 times a day,a total of eight weeks,and at the same time,ornidazole and clarithromycin was taken orally for 4 weeks.The control group was treated with 0.1%tacrolimus ointment besmear outside 2 times a day for a total of eight weeks .The curative effects of two groups after treatment,and the symptom rebound rates aftre 4 weeks of treatment were compared .Results The total effective rate of the observation group was 92.5%,which of the control group was 67.5%,the difference between the two groups was statistically significant（χ2 =7.68,P〈0.05）.The symptom scores before treatment between the two groups had no statistically significant difference[（19.93 ±0.76）points vs.（19.89 ±4.07）points,P〉0.05].After treatment, the symptom scors between the two groups had statistically significant difference （P〈0.05）.The bounce rate of the observation group was 7.5%,which of the control group was 31.58%.The difference between the two groups was statistically significant（χ2 =5.97,P〈0.05）.Conclusion 0.1%tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea complicated with hormone-dependent facial dermatitis has satisfied curative effect and security ,the comprehensive treatment is better than single treatment .