炎性因子在支气管哮喘急性发作患者血清中的表达及意义

Expression of inflammatory factors in serum of patients with acute bronchial asthma

目的探讨支气管哮喘急性发作患者血清中炎性因子的变化。方法将支气管哮喘急性发作患者92例,根据病情严重程度分为2组,选择体检健康人作为对照,检测肺功能及血清白细胞介素(IL)-6、IL-17、肿瘤坏死因子(TNF)-α、γ-干扰素(IFN-γ)、转化生长因子β2(TGF-β2)水平。结果与对照组相比,哮喘组IL-6、IL-17、TNF-α均明显增高,而IFN-γ明显降低(P<0.01),3组TGF-β2差异无统计学意义(P>0.05)。哮喘严重程度与IL-6、TNF-α、IL-17呈正相关(r=0.970、0.868、0.723,P<0.05)。与FEV1/FVC及IFN-γ呈负相关(r=-0.957、-0.934,P<0.05);与TGF-B2无相关性(r=0.321,P>0.05)。结论血清炎性因子变化与哮喘的发病密切相关,对哮喘严重程度的评估具有一定的参考价值。

Objective To investigate the changes of inflammatory factors in the serum of patients with acute bronchial asthma.Methods Totally 92 patients with bronchial asthma were divided into two groups according to the degree of severity of acute bronchial asthma,including healthy people as the controls.Lung function and serum interleukin(IL)-6,IL-17,tumor necrosis factorα(TNF-α)and interferon gamma(IFN-γ),transforming growth factorβ2(TGF-β2)level were detected.Results Compared with the control group,the IL-6,IL-17 and TNF-αin the asthma group were significantly increased,while IFN-γ was significantly lower(P <0.01),and there was no significant difference between the 3 groups of TGF-β2(P >0.05).There were positive correlations between the severity of asthma and IL-6,TNF-a and IL-17(r =0.970,0.868,0.723,P <0.05).Severity of asthma was negatively correlated with FEV1/FVC and IFN-gamma(-0.957,-0.934,P <0.05),and not correlated with TGFB2(r=0.321,P >0.05).Conclusion The increase of serum inflammatory factors in patients with bronchial asthma is closely related to the incidence of asthma,and it is of certain reference value for the assessment of the severity of asthma.