观察糖皮质激素治疗间质性肺病急重症的效果

Observation on the effect of glucocorticoids on the treatment of severe acute interstitial lung disease

目的分析糖皮质激素治疗间质性肺病急重症患者的临床效果。方法 78例间质性肺病急重症患者,随机分为对照组和观察组,各39例。对照组采用常规方案治疗,观察组患者辅以糖皮质激素进行治疗,观察两组患者氧合指数、动脉血二氧化碳分压、动脉血氧分压及肺容量、气体交换、弥散量及运动后气体交换评分情况。结果治疗后,观察组血氧分压、动脉血二氧化碳分压、氧合指数分别为(71.45±2.34)mm Hg(1mm Hg=0.133 k Pa)、(38.24±1.24)mm Hg、(345.54±10.38),均优于对照组的(38.54±1.57)mm Hg、(43.57±1.77)mm Hg、(214.72±9.64),差异有统计学意义(P<0.05)。治疗后,观察组肺容量、弥散量、气体交换、运动后气体交换评分均优于对照组,差异有统计学意义(P<0.05)。结论针对间质性肺疾病急重症患者借由糖皮质素进行治疗,能针对患者各项肺功能指标进行有效改善,在稳定病情的同时,促进其恢复,对于改善该部分患者生活质量同样具备有积极意义。

Objective To analyze the clinical effect of glucocorticoids on the treatment of severe acute interstitial lung disease. Methods A total of 78 patients with severe acute interstitial lung disease were randomly divided into control group and observation group, with 39 cases in each group. The control group was treated with conventional regimen, and the observation was treated with glucocorticoids. Observation were made on oxygenation index, arterial blood carbon dioxide partial pressure, arterial oxygen partial pressure and lung capacity, gas exchange, diffusion, and post-exercise gas exchange score between the two groups. Results The observation group had blood oxygen partial pressure, arterial blood carbon dioxide partial pressure, oxygenation index respectively as（71.45±2.34） mm Hg（1 mm Hg=0.133 k Pa）,（38.24±1.24） mm Hg and（345.54±10.38）, which were all better than（38.54±1.57） mm Hg,（43.57±1.77） mm Hg and（214.72±9.64） in the control group, and their difference was statistically significant（P〈0.05）. After treatment, the observation group had better lung capacity, diffusion, gas exchange, and post-exercise gas exchange score than the control group, and the difference was statistically significant（P〈0.05）. Conclusion Application of glucocorticoids for patients with severe acute interstitial lung disease can effectively improve pulmonary function indicators and promote their recovery while stabilizing the condition. It also has positive significance for improving the quality of life of these patients.