特种红曲对鹌鹑实验性脂肪肝的治疗作用

Effect of monascus purpureus fermented rice on fatty liver in quails

目的 :观察特种红曲对鹌鹑实验性脂肪肝的影响 ,以确证其治疗效果。方法 :建立乙醇性脂肪肝鹌鹑模型 ,测定给药前后的血脂和肝脂水平 ,并进行肝脏病理组织学检查。结果 :特种红曲 1 .6g·kg-1给脂肪肝鹌鹑灌胃 2 0d ,可明显降低血浆总胆固醇(TC) ,甘油三酯 (TG)和低密度脂蛋白 (LDL)水平 (P<0 .0 1 ) ,同时降低肝脏TC和TG水平 (P <0 .0 1 ) ;特种红曲 0 .8g·kg-1也可降低血浆TC和LDL水平(P <0 .0 5 )和肝脏TC水平 (P <0 .0 1 ) ,并可使肝组织的脂变程度明显减轻 ,部分动物的肝脏甚至完全恢复正常。结论

AIM: To investigate the effect of monascus purpureus fermented rice (MR) on alcohol fatty liver model in quails. METHODS: A fatty liver model was established in quails, then the lipid levels of the models were tested in both plasma and liver, and the examination in the pathological histology of liver was conducted. RESULTS: 1.6 g·kg -1 ·d -1 of MR given orally for 20 d significantly decreased TC, TG and LDL (P< 0.01 ) in serum, and TC, TG in liver of quails. 0.8 g·kg -1 ·d -1 of MPFR also decreased TC and LDL in serum (P< 0.05 ) and TC in liver (P< 0.01 ). MR lowered the rate of liver fatty degeneration with a dose dependent manner and reduced the degree of liver fatty degeneration. CONCLUTION: MR shows a therapeutic efficacy on alcoholic fatty liver model in quails, suggesting that it may be used as a kind drug or a kind of health food in prevention or treatment of patients with fatty liver.