格列吡嗪控释片治疗II型糖尿病的临床疗效评价

Clinical evaluation of the efficiency of controlled-release formulation of glipizide in the treatment of type II diabetes mellitus

目的 :对比研究格列吡嗪控释片与格列吡嗪速释片对Ⅱ型糖尿病的疗效。方法 :选择 80例Ⅱ型糖尿病患者 ,给予格列吡嗪控释片 (n =5 0 )和格列吡嗪速释片 (n =3 0 )治疗 ,观察两组治疗前后血糖和胰岛素的变化。结果 :格列吡嗪控释片每日一次服用的降糖效果与格列吡嗪速释片每日 2～ 3次服用效果相同 ;后者治疗后空腹和餐后胰岛素较前者明显升高。结论 :格列吡嗪控释片有较好的降糖效果 。

AIM: To compare the efficacy between a once daily controlled release formulation of glipizide (CRFG) and immediate release glipizide (IRG) in patients with type Ⅱ diabetes mellitus. METHODS: 80 patients with type Ⅱ diabetes mellitus were divided into the CRFG group and the IRG group to observe the levels of blood glucose and insulin after the treatments. RESULTS: CRFG given qd and IRG given bid or tid showed a similar effect, but the levels of fasting and post prandial insulin in latter was higher than that in the former. CONCLUSION: The controlled release formulation of glipizide can effectively control blood glucose without hyperinsulinemia in patients with type Ⅱ diabetes mellitus.