血液灌流抢救超大剂量地高辛中毒

Hemoperfusion in treatment of overdose digoxin poisoning

目的 :观察 1例血液灌流抢救超大剂量 (5 0mg)地高辛中毒的效果。方法 :使用HA 3 3 0ml灌流器和YT 1 60灌流器 ,血管通路为股静脉单针双腔导管。入院后共进行了 4次血液灌流 (HP)治疗。结果 :第1次HP前后检测地高辛血药浓度均 1 6μg·L-1。第2次HP血药浓度 9.2 2 μg·L-1。第 3次HP前血药浓度 1 2 .4μg·L-1,HP后为 1 0 .45 μg·L-1。第 4次HP前 3 .2 2 μg·L-1,HP后为 2 .84μg·L-1。结论 :采用间隔一定的时间HP,多次进行 ,可阶梯式降低药物浓度。

AIM: To observe the efficacy of hemoperfusion (HP) to treat one case suffering from overdose digoxin poisoning. METHODS: HA 330 ml and YT 160 hemoperfusion cartridges were used and blood vessel was femoral vein, single needle and two chamber catheter. Four HP were done. RESULTS: The blood digoxin level were 16 μg·L -1 before and after the 1st HP, 9.22 μg·L -1 at the 2nd, 12.4 μg·L -1 before the 3th, 10.45 μg·L -1 after the 3th, 3.22 μg·L -1 before the 4th, and 2.84 μg·L -1 after the 4th HP. CONCLUSION: This case demonstrats that multiple HP at different period may decrease the blood digoxin level step by step.