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UGT1A1基因多态性与伊立替康治疗结直肠癌疗效及安全性的关系 被引量:5

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摘要 伊立替康(irinotecan,CPT-11)是一种治疗转移性结直肠癌的特效药,为喜树碱半合成衍生物,在体内被羧酸酯酶水解后抑制细胞周期S期DNA单链断裂后的修复过程,从而干扰DNA的复制和转录。
出处 《浙江中西医结合杂志》 2018年第3期193-197,共5页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
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  • 1季楚舒,何义富,胡冰,王刚,姚艺伟,陈健,单本杰,孙玉蓓,王勇,江丰收,胡长路.UGT1A1*28基因多态性与晚期结直肠癌伊立替康化疗疗效及不良反应的关系[J].肿瘤,2010,30(10):870-874. 被引量:18
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