高锰酸钾氧化水中沙拉沙星的动力学研究

Kinetics study on sarafloxacin oxidization by permanganate in aqueous environment

选用高锰酸钾为氧化剂从动力学的角度研究高锰酸钾初始浓度,p H值和温度对沙拉沙星氧化反应速率的影响,并比较高锰酸钾氧化其他氟喹诺酮类药物(恩诺沙星,氧氟沙星,环丙沙星,诺氟沙星)的动力学参数,旨在为沙拉沙星污染治理提供科学依据和建议.研究得出:氧化过程符合二级反应动力学规律,随着高锰酸钾浓度和环境温度的升高,反应速率增加;相对于中性条件和碱性条件[K=30~47L/(mol·min)],酸性条件(p H=4~5)下其反应速率[K=66~91.28L/(mol·min)]要明显更快.高锰酸钾氧化沙拉沙星的动力学参数与环丙沙星的类似,在相关研究中可以适当参考环丙沙星的处理参数.

By evaluating the effects of initial concentration of KMnO4, pH and temperature, experimental studies ofsarafloxacin oxidation kinetics by potassium permanganate were investigated. Meanwhile, the kinetics parameters of otherfluoroquinolones （e.g. enrofloxacin, ofloxacin, ciprofloxacin, norfloxacin） were compared with those of sarafloxacin, thusproviding a feasible approach for degradation and removal of sarafloxacin in the aquatic environment. The resultsindicated that the kinetic rate of sarafloxacin oxidization by potassium permanganate in the aqueous solution followed thesecond-order kinetics model. An increase in the initial KMnO4 concentration or temperature corresponded to an increasein the reaction rate. Furthermore, the reaction rate [K=66-91.28L/（mol·min）] under acidic conditions （pH=4-5） wasobviously higher than that [K=30-47L/（mol·min）] under the neutral and alkaline conditions. The kinetic parameters ofsarafloxacin were similar to those of ciprofloxacin, which could be validated for the determination of relevant parametersof sarafloxacin.