紫杉醇联合卡铂化疗治疗宫颈癌的效果观察

Effect of paclitaxel combined with carboplatin chemotherapy in treatment of cervical cancer

目的观察并探讨术前采用紫杉醇联合卡铂新辅助化疗方式对晚期宫颈癌患者的效果。方法将2013年1月—2015年1月在焦作煤业(集团)有限责任公司中央医院接受住院治疗的30例局部晚期宫颈癌患者作为研究对象进行研究,对其临床资料进行回顾性分析,根据治疗方式的不同将其分为对照组和研究组,每组15例。其中对照组患者仅给予手术治疗,比较两组患者的近期治疗有效率和不良反应发生率。结果研究组患者近期治疗总有效率为86.67%,对照组为53.33%,两组比较存在显著性差异(P<0.05);研究组患者在化疗期间主要出现的不良反应有脱发11例、消化道15例以及12例患者出现功能损伤等,但所有出现不良反应的患者病情均在1度以内。结论对局部晚期宫颈癌患者,手术治疗前进行紫杉醇联合卡铂新辅助化疗可以有效缩小肿瘤范围,有助于提高宫颈癌患者临床近期治疗有效率。

Objective To study the effect of paclitaxel combined with carboplatin neoadjuvant chemotherapy on patients with locally advanced cervical cancer before operation and observe the clinical therapeutic effect.Methods Thirty patients with locally advanced cervical cancer treated in our hospital from January 2013 to January 2015 were randomly divided into study group and control group according to the different treatment regimen.Fifteen patients in the control group were treated by surgery,15 patients in the study group before surgery by paclitaxel combined with carboplatin neoadjuvant chemotherapy,compared the effective rate of the two groups.Results In the study group,the effective rate of immediate clinical treatment was 86.67%,which was significantly higher than that of the control group（53.33%）.The difference was statistically significant（P 0.05）.In the study group,The main adverse reactions were alopecia in 11 cases,15 cases of digestive tract and 12 cases with functional damage,but all patients with adverse reactions were within 1 degree.Conclusions Paclitaxel combined with carboplatin neoadjuvant chemotherapy can shorten the tumor range effectively in patients with locally advanced cervical cancer before operation.It is helpful to improve the clinical effective treatment of cervical cancer patients.