胎盘多肽对老年局部晚期非小细胞肺癌放疗患者生活质量及免疫功能的影响

Effect of Placenta Polypeptide injection on the quality of life and immune function of non-small cell lung cancer patients with radiotherapy

目的观察胎盘多肽对老年晚期非小细胞肺癌放疗患者生活质量及免疫功能的影响。方法选取2016年1月—2016年8月在河南大学淮河医院住院的老年非小细胞肺癌患者82例随机分为观察组和对照组。两组患者给予常规三维适形放射治疗。观察组患者放疗期间给予胎盘多肽,治疗前、中、后定期监测患者外周血白细胞变化,分别于放疗开始前一周及放疗结束后1个月复查胸部CT及免疫功能的变化。结果观察组近期总有效率与对照组比较无统计学差异(P>0.05)。治疗后,观察组患者整体生活质量评分及体质量增加都高于对照组(均P<0.01)。治疗后观察组外周血CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、NK细胞百分率较化放疗前升高(P<0.05),放疗后对照组观察各项指标低于放疗前(P<0.05)。放疗后观察组后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、NK细胞活性明显高于对照组(P<0.01)。放疗后观察组白细胞、血小板减少程度明显低于对照组。结论胎盘多肽联合三维适形放射治疗老年晚期非小细胞肺癌,显著增强T细胞亚群及NK细胞活性,改善患者免疫力,显著改善老年晚期非小细胞肺癌患者生活质量,缓解放疗所致的不良反应,缓解放疗引起的白细胞及血小板减少,减轻骨髓抑制。

Objective To investigate the effects of Placenta Polypeptide injection on the quality of life（Qo L） and immunefunction of lung cancer patients with three-dimensional conformal radiotherapy（3D-CRT）.Methods The 82 cases of elderly non-small cell lung cancer patients who were hospitalized in our hospital from January 2016 to August 2016 were randomly divided into observation group and control group.Two groups of patients were given regular three ‐dimensional conformal radiotherapy（3D-CRT）,patients of the observation group was given placental polypeptide during radiotherapy,In all patients,the changes of white blood cells in peripheral blood cells were monitored regularly before and after treatment,and the changes of CT and immune function were reviewed one week before radiotherapy and 1 month after radiotherapy.Results There was no statistically significant difference between the observed group and the control group（PBBB 00.05）.After treatment,the overall quality of life of the observation group and the weight gain were higher than the control group（all P 0.01）.After treatment,peripheral blood CD3~＋,CD4~＋,CD8~＋,CD4~＋/CD8~＋ and NK cell percentage were increased before radiotherapy（p 0.05）.After radiotherapy,the control group was observed after radiotherapy（P 0.05）.After radiotherapy,the activity of CD3~＋,CD4~＋,CD8~＋,CD4~＋/CD8~＋ and NK cells was significantly higher than that in the control group（P 0.01）.After radiotherapy,the decrease of white cells and platelets was significantly lower than that in the control group.Conclusion Placenta polypeptide combined three dimensional conformal radiotherapy in elderly advanced non-small cell lung cancer,significantly enhanced the T cells subgroup and NK cell activity,improve immunity,and significantly improve the old patients with advanced non-small cell lung cancer quality of life,alleviate adverse reaction caused by radiotherapy,ease of white blood cells caused by radiotherapy and thrombocytopenia,reduce bone marrow suppression.