丙戊酸单独应用及联合奥氮平治疗双相Ⅰ型障碍急性躁狂发作疗效比较

Clinical comparison of combined with olanzapine sodium valproate alone and in the treatment of acute manic episodes with bipolar disorder

目的对比丙戊酸钠单独应用及联合奥氮平治疗双相Ⅰ型障碍急性躁狂发作的临床疗效。方法将医院2015年1月-2017年1月收治的双相Ⅰ型障碍急性躁狂发作50例患者随机分成试验组和对照组各25例。试验组患者使用奥氮平联合丙戊酸钠治疗;对照组患者使用丙戊酸钠单独治疗。治疗1个疗程后比较2组患者的治疗疗效及不良反应发生情况。结果治疗第2周、第4周、第6周试验组的总有效率均明显高于对照组,差异均有统计学意义(P<0.05)。试验组不良反应发生率为16%,对照组为20%,2组不良反应发生率比较差异无统计学意义(χ2=1.361,P>0.05)。结论奥氮平联合丙戊酸钠对患者的双相Ⅰ型障碍急性躁狂发作治疗疗效明显优于单独使用丙戊酸钠。

Objective To compare the efficacy of sodium valproate alone or combination with olanzapine in the treatment of acute manic episodes with bipolar disorder. Methods 50 patients with acute manic episode of bipolar I disorder admitted to the hospital in the past two years were randomly divided into control group and test group,each of 25 cases. Patients in test group were treated with olanzapine in combination with sodium valproate; patients in control group were treated with sodium valproate alone. After a course of treatment,the curative effect and adverse reaction of two groups were compared. Results The total effective rate in the second,fourth and sixth week of treatment group was significantly higher than that of control group,the difference was statistically significant（P〈0. 05）. The incidence of adverse reactions was 16% in test group and20% in control group,there was no significant difference in the incidence of adverse reactions between two groups（χ2= 1. 361,P〈0. 05）. Conclusion Olanzapine combined with sodium valproate is superior to the use of sodium valproate alone in the treatment of patients with bipolar disorder.