类风湿关节炎并冠心病患者甲襞微循环状态变化情况

Nailfold microcirculation status changes of patients with rheumatoid arthritis complicated with coronary heart disease

目的探讨类风湿关节炎并冠心病患者甲襞微循环状态变化情况。方法选取德阳市人民医院2016年1月—2017年1月收治的类风湿关节炎并冠心病患者54例为A组,另选取本院同期类风湿关节炎患者54例为B组,冠心病患者54例为C组,健康体检者54例为D组,检测比较4组受试者甲襞微循环加权积分(襻周状态积分、血流状态积分、管襻形态积分及总积分)及其他指标(管襻畸形率、白微栓率、输入枝长度及输出枝长度)。结果A组患者襻周状态积分、血流状态积分、管襻形态积分及总积分高于B、C、D组(P<0.05);B、C组患者襻周状态积分、血流状态积分、管襻形态积分及总积分高于D组(P<0.05)。B、C组患者襻周状态积分、血流状态积分、管襻形态积分及总积分比较,差异无统计学意义(P>0.05)。A组患者管襻畸形率、白微栓率高于B、C、D组,输入枝长度、输出枝长度短于B、C、D组(P<0.05);B、C组患者襻畸形率、白微栓率高于D组,输入枝长度、输出枝长度短于D组(P<0.05)。B、C组患者襻畸形率、白微栓率及输入枝长度、输出枝长度比较,差异无统计学意义(P<0.05)。结论类风湿关节炎并冠心病患者甲襞微循环状态相对较差,应针对患者的微循环状态变化情况进行针对性干预。

Objective To observe nailfold microcirculation status changes of patients with rheumatoid arthritis complicated with coronary heart disease.Methods A total of 54 cases of patients with rheumatoid arthritis complicated with coronary heart disease were selected from January 2016 to January 2017 in the People＇s Hospital of Deyang City as A group,54 cases of patients with rheumatoid arthritis at the same time were selected as B group,54 cases of patients with coronary heart disease were selected as C group,54 healthy people with physical examination were selected as D group.The weighted integral of nailfold microcirculation（weighted integral of perivascular tissue status,blood flow state integral,tube loop form integral,aggregate score） and the others indexes（tube loop deformity rate,microembolus rate,input branch length,output branch length） were compared between the two groups.Results The A group of weighted integral of perivascular tissue status,blood flow state integral,tube loop form integral,aggregate score were higher than B,C,D group（P〈0.05）; the B,C group of weighted integral of perivascular tissue status,blood flow state integral,tube loop form integral,aggregate score were higher than D group（P〈0.05）,No significant differences of weighted integral of perivascular tissue status,blood flow state integral,tube loop form integral or aggregate score was found between the B group and C group（P〈0.05）.The A group of tube loop deformity rate,microembolus rate were higher than B,C,D group,input branch length,output branch length were shorter than B,C,D group（P〈0.05）; the B,C group of tube loop deformity rate,microembolus rate were higher than D group,input branch length,output branch length were shorter than D group（P〈0.05）.No significant differences of tube loop deformity rate,microembolus rate,input branch length or output branch length was found between the B group and C group（P〈0.05）.Conclusion The nailfold microcirculation state of rheumatoid arthritis complicated with coronary heart disease patients are relatively worse,and we should be paid to targeted intervention according to the changes of microcirculation.